Detailed information of TA system TA201604

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 244102..244853
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: KGP26_RS01050
• Protein ID: WP_179249315.1
• Coordinates: 244102..244584 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A3G2FKC3
• Locus tag: KGP26_RS01055
• Protein ID: WP_059199145.1
• Coordinates: 244575..244853 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS01025 (KGP26_01020)	239417..240460	+	1044	WP_021807714.1	TerC/Alx family metal homeostasis membrane protein	-
KGP26_RS01030 (KGP26_01025)	240518..241096	+	579	WP_021807715.1	tellurium resistance membrane protein TerD	-
KGP26_RS01035 (KGP26_01030)	241169..241744	+	576	WP_021807716.1	TerD family protein	-
KGP26_RS01040 (KGP26_01035)	241938..243182	+	1245	WP_223664912.1	VWA domain-containing protein	-
KGP26_RS01045 (KGP26_01040)	243253..243951	-	699	WP_037376573.1	HAD family hydrolase	-
KGP26_RS01050 (KGP26_01045)	244102..244584	-	483	WP_179249315.1	GNAT family N-acetyltransferase	Toxin
KGP26_RS01055 (KGP26_01050)	244575..244853	-	279	WP_059199145.1	DUF1778 domain-containing protein	Antitoxin
KGP26_RS01060 (KGP26_01055)	245072..246106	+	1035	WP_223664913.1	YeeE/YedE family protein	-
KGP26_RS01065 (KGP26_01060)	246112..246339	+	228	WP_059199143.1	sulfurtransferase TusA family protein	-
KGP26_RS01070 (KGP26_01065)	246535..246771	+	237	WP_021807719.1	DUF4282 domain-containing protein	-
KGP26_RS01075 (KGP26_01070)	246841..247590	-	750	WP_223664914.1	NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17670.60 Da
• Isoelectric Point: 9.9599

>T201604 WP_179249315.1 NZ_CP074143:c244584-244102 [Serratia sp. JSRIV002]
MGMKAPEPLSSGHNLADFCSSEPMLNEWLRKKALKNHSAGISRVYVICTEETHRVIGYYCLATGSVQRNTAPGAYRRNAP
ESLPVIVLGRLAIDQAYSGKGLGVALLKDAIFRTKNIAQQVGVRALIVHALNEGVRNFYIKFAFSPSPEHPLMLFYPIKL

Nucleotide

• Length: 483 bp

>T201604 NZ_CP098691:1921341-1921799 [Yersinia ruckeri]
GTGATGCTCTACCGGATAGTTCACAACCGTTACCTGGCAACGGCCTGGACCGGATATGGCGCAGAAACCTATGGTGGCCG
CTGGAATCATAAAGGCCATGCGGCGATTTATCTGGCCAGTAGCGTTTCTCTGGCGATGCTCGAAACACTGGTGCATGTAG
AAGATAGCGCGACGCTGAACGATTTTAATCTATTTCAGATAACCATTCCCGATAATGCAATTATGGTACTGCAACAGCAA
GATTGGCCACGTGGATGGCGAGATGACCCCACCCCCGTGGCCACCATGGACATCGGCACCGAATGGATTGGTTCAGTATC
ATCTGTCGGTCTGCTGGTACCATCCACGTTAGTCCCTTTGGAAAGAAATATGCTGGTGAATCCTAAACACCGCGATTTCG
CCTCGTGCCTGAAAAGCATCAATCCACTGACGTTCAGTTTTGATCCTCGTCTAAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10641.12 Da
• Isoelectric Point: 4.4247

>AT201604 WP_059199145.1 NZ_CP074143:c244853-244575 [Serratia sp. JSRIV002]
MKPETREAPINIRAKASQRDLIDMAASLLSKSRTDFMLEVACREAQDILLDQRLFILDDEQYDAFLTELDAPITAERQAR
INDLMSRKSPWE

Nucleotide

• Length: 279 bp

>AT201604 NZ_CP098691:1920881-1921327 [Yersinia ruckeri]
ATGAGAACTTATCACCCAAGCCCGATGGCCAAAGTCAGCGCACTATGGCGTGAGATTGGTCTACCCGCCAGTCGTGGCAC
CGCTTTGGTGGACAGCATAAAACTGGGATTTACTGTGGATGTGATCGACACTATACATTTATGGGCTGATATGCCTAAAT
CTGAAATATTACGCGCTACGGGCATTCCGAGCCGCAGTCTGACGCGCCGTCGTACCCATGATGGGCGTTTTACCCCGGAA
GAAAGCGAACGTATTGCACGGTTTGTCCGGGTTATGGATGCGGCGGTAGATTTGTTCGGTGGTGACCGCACCAAAGCAAC
CGCATGGATGTCGATGCCGGTCAAAGGGCTGGGTAATCGAACGCCCGATTCACTGCTGGAAACCGAAACCGGTGCGTTGG
AAATCTGCGACCTGATTGGTCGTCTCGAACATGGGGTCTTTTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3G2FKC3