Detailed information of TA system TA201602

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 133459..134155
• Replicon: chromosome
• Accession: NZ_CP074143
• Organism: Serratia sp. JSRIV002

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: KGP26_RS00525
• Protein ID: WP_223536849.1
• Coordinates: 133459..133794 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: KGP26_RS00530
• Protein ID: WP_223536852.1
• Coordinates: 133871..134155 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP26_RS00495 (KGP26_00495)	129580..129990	+	411	WP_223536836.1	hypothetical protein	-
KGP26_RS00500 (KGP26_00500)	130056..130997	+	942	WP_223536837.1	hypothetical protein	-
KGP26_RS30295	131133..131258	+	126	WP_256461389.1	hypothetical protein	-
KGP26_RS00505 (KGP26_00505)	131633..132079	+	447	WP_223536838.1	antirestriction protein	-
KGP26_RS00510 (KGP26_00510)	132097..132585	+	489	WP_223536841.1	DNA repair protein RadC	-
KGP26_RS00515 (KGP26_00515)	132579..132899	+	321	WP_223536844.1	DUF5983 family protein	-
KGP26_RS00520 (KGP26_00520)	132963..133445	+	483	WP_223536847.1	hypothetical protein	-
KGP26_RS00525 (KGP26_00525)	133459..133794	+	336	WP_223536849.1	TA system toxin CbtA family protein	Toxin
KGP26_RS00530 (KGP26_00530)	133871..134155	+	285	WP_223536852.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KGP26_RS00535 (KGP26_00535)	134245..135102	+	858	WP_223536855.1	DUF4942 domain-containing protein	-
KGP26_RS00540 (KGP26_00540)	135528..135793	-	266	Protein_107	transposase	-
KGP26_RS00545 (KGP26_00545)	136075..137238	-	1164	WP_223536857.1	DUF4238 domain-containing protein	-
KGP26_RS00550 (KGP26_00550)	137715..138599	-	885	WP_223536860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	123919..198888	74969

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (15-104)

Antitoxin

• Antitoxin CbeA (14-90)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12485.26 Da
• Isoelectric Point: 5.0858

>T201602 WP_223536849.1 NZ_CP074143:133459-133794 [Serratia sp. JSRIV002]
MKAIDKIPHTAPNANQALAEYEQLLTWLLNHCYGLELNDTPYHDPQAIAQQIEYGMTVRETINELVEKFDLVRIDRPGFS
LLAQDPTLSGGDMLLARSALGLRNPVNRRLA

Nucleotide

• Length: 336 bp

>T201602 NZ_CP098691:457650-458306 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10424.05 Da
• Isoelectric Point: 6.7069

>AT201602 WP_223536852.1 NZ_CP074143:133871-134155 [Serratia sp. JSRIV002]
MKNLEPDIPPTAPVWGLQCAITPRLGARLVQQGRHLHFLADRAGLIGTFTPEAIKALDVAFPVLIEQLENYLRSGELDPR
RQHCVTVQLSPSTE

Nucleotide

• Length: 285 bp

>AT201602 NZ_CP098691:458303-459370 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA