Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5098920..5099710 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP21_RS24305 Protein ID WP_223498453.1
Coordinates 5098920..5099255 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP21_RS24310 Protein ID WP_223498454.1
Coordinates 5099333..5099710 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS24265 (KGP21_24175) 5094748..5095452 + 705 WP_223498446.1 transcriptional regulator -
KGP21_RS24270 (KGP21_24180) 5095452..5096021 + 570 WP_223499718.1 hypothetical protein -
KGP21_RS24275 (KGP21_24185) 5096060..5096512 + 453 WP_223498447.1 hypothetical protein -
KGP21_RS24280 (KGP21_24190) 5096509..5096961 + 453 WP_223498448.1 IrmA family protein -
KGP21_RS24285 (KGP21_24195) 5097107..5097541 + 435 WP_223498449.1 antirestriction protein -
KGP21_RS24290 (KGP21_24200) 5097559..5098047 + 489 WP_223498450.1 DNA repair protein RadC -
KGP21_RS24295 (KGP21_24205) 5098041..5098361 + 321 WP_223498451.1 DUF5983 family protein -
KGP21_RS24300 (KGP21_24210) 5098425..5098907 + 483 WP_223498452.1 hypothetical protein -
KGP21_RS24305 (KGP21_24215) 5098920..5099255 + 336 WP_223498453.1 TA system toxin CbtA family protein Toxin
KGP21_RS24310 (KGP21_24220) 5099333..5099710 + 378 WP_223498454.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP21_RS24315 (KGP21_24225) 5099789..5100646 + 858 WP_223498455.1 DUF4942 domain-containing protein -
KGP21_RS24320 (KGP21_24230) 5100763..5101044 + 282 WP_223498456.1 ribbon-helix-helix domain-containing protein -
KGP21_RS29600 5101184..5101318 + 135 WP_245398320.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP21_RS24330 (KGP21_24240) 5101610..5102722 - 1113 WP_223500374.1 M20 family metallopeptidase -
KGP21_RS24335 (KGP21_24245) 5102819..5103280 - 462 WP_115159346.1 YjiG family protein -
KGP21_RS24340 (KGP21_24250) 5103297..5104031 - 735 WP_155621780.1 nucleoside recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaSFC-1 - 5066841..5101163 34322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(15-102)

Antitoxin

Antitoxin CbeA

(25-123)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12531.36 Da        Isoelectric Point: 6.2133

>T201596 WP_223498453.1 NZ_CP074140:5098920-5099255 [Serratia sp. JSRIV004]
MKTMNKLPHTPSNASPAFLEYQQLLAWLLAHCYGLELNDTPYHDDQAITQQIEYGVTVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLSAGDMLCARSARGLRSPVIRRLA

Download         Length: 336 bp

>T201596 NZ_CP098611:3205268-3205522 [Phormidium yuhuli AB48]
ATGAAAACCATTGAAACTCAACAAGCCAAACAGCAATTAGATGAGATGATTGACCAGGTTATTATAGATGTTGAACCGAC
AATCCTACGGAATCAAAAGGGTCAAGAAGCGGTTTTGATGTCGTTAGAAGAGTTTAGTGCTTGGCGGGAAACGATTTATC
TTTTATCCAATCCAGCCAATGCGTCTCATCTTCTTGAATCTATCAAGCAGGCTGAGTCAGGTCAGACTATCCTCAAGGAA
CTTCTGGATGAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13783.81 Da        Isoelectric Point: 6.9474

>AT201596 WP_223498454.1 NZ_CP074140:5099333-5099710 [Serratia sp. JSRIV004]
MKEPVLNTDNNAAPLTDEDNIPSPVWGLHCAITPRLGARLVQKGNRLHFLPDRAGFVGMFSPDALKTLDRAFPVLIKLLE
ACLRSGELDQRRQHCVTVQHAGFTCEADTLGSFGHVYLAVYQTPT

Download         Length: 378 bp

>AT201596 NZ_CP098611:3205519-3205779 [Phormidium yuhuli AB48]
ATGAAGGTAAGTTTTACTGAGTTGGCTTGGTCTGATTATCTCTGGCTACAAAAGAAGGATAAGAGGCTTTTAAAACGGGT
AAATCTTCTGATTAAAGATGTGATGAGGGATGCGTTTGAGGGGATTGGCAAGCCAGAACCTTTGAAGGGAAATTTATCGG
GTTACTGGTCAAGGCGGATTGATGGGGAGCATCGTTTGGTGTATCAGGTGGTTGGAGATGAAATTTTAATTATTTCCTGT
CGGTTTCACTATGAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References