Detailed information of TA system TA201595

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4799902..4800571
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8H9YD80
• Locus tag: KGP21_RS22845
• Protein ID: WP_071681918.1
• Coordinates: 4799902..4800324 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: KGP21_RS22850
• Protein ID: WP_021179805.1
• Coordinates: 4800305..4800571 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS22825 (KGP21_22745)	4795746..4796264	+	519	WP_021179810.1	flavodoxin FldB	-
KGP21_RS22830 (KGP21_22750)	4796300..4797688	-	1389	WP_223500291.1	cell envelope integrity protein CreD	-
KGP21_RS22835 (KGP21_22755)	4797792..4799210	-	1419	WP_021806194.1	two-component system sensor histidine kinase CreC	-
KGP21_RS22840 (KGP21_22760)	4799207..4799902	-	696	WP_021806195.1	two-component system response regulator CreB	-
KGP21_RS22845 (KGP21_22765)	4799902..4800324	-	423	WP_071681918.1	protein YgfX	Toxin
KGP21_RS22850 (KGP21_22770)	4800305..4800571	-	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
KGP21_RS22855 (KGP21_22775)	4800872..4801864	+	993	WP_223501552.1	tRNA-modifying protein YgfZ	-
KGP21_RS22860 (KGP21_22780)	4801904..4802401	-	498	WP_021806198.1	DUF2165 domain-containing protein	-
KGP21_RS22865 (KGP21_22785)	4802633..4803307	-	675	WP_037375710.1	hemolysin III family protein	-
KGP21_RS22870 (KGP21_22790)	4803544..4804152	+	609	WP_094981477.1	HD domain-containing protein	-
KGP21_RS22875 (KGP21_22795)	4804186..4804932	-	747	WP_115159283.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16523.49 Da
• Isoelectric Point: 10.6373

>T201595 WP_071681918.1 NZ_CP074140:c4800324-4799902 [Serratia sp. JSRIV004]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLLFEQSATDEDV

Nucleotide

• Length: 423 bp

>T201595 NZ_CP098611:c3178380-3177883 [Phormidium yuhuli AB48]
GTGTCTTCGGAACAGCCAATTATCATCAACGGATGGACTCTGTTTGCTCATCCTCTGTTTCTGAGCCAGGTCGAGACTCT
GGTAACCCAGGTCGAACGGTTGCGCCAGAAAGATGCCCAGGGCTATAAACGGAAAAACGTAACGAAGCGTCTGGCGGCGA
TCGCCCGGCTGGCCTTTGAGATTATACCGGAGGATCCAACCCGTCCCAACTATCGCCAAGGCTCAACCCTTGGACCGGAG
TATAAACATTGGTTTCGCGCTAAATTCTTCCAACAATACCGACTCTTTTTCAGATATCACCAAGAGAGCAAAATTATCGT
CTTGGCTTGGGTGAATGACGAAACATCCAAGCGTGCTTATGACCGTGATACCGATGCCTATCGGGTTTTTGCCAAGATGT
TGGATCAGGGTCACCCCCCCGATGATTGGGAGGCGTTGATGCAAGAGGTCAGCCAGACAACGGAACGTCTGAAAAAAATT
CTCGACCAAGAAATTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT201595 WP_021179805.1 NZ_CP074140:c4800571-4800305 [Serratia sp. JSRIV004]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT201595 NZ_CP098611:c3178715-3178383 [Phormidium yuhuli AB48]
ATGGCTAGACCCTCACAGCCTTGTTCAGAATCAACCCTGACTGCTCGTTATCAGACGACGATTCCTGAGCCAATCCGAAA
ATTTCTCGGGTTAGCGAAAGGAGACAAAATCCAGTACAGCATTGAGCCGGACGGACAAGTCTTGATTTCGGTGGCGAAAG
ATAGCAGTGACGATCCAGTTCTCGGAGCTTTTTTAGAATTTATCGAACAGGATATGAGCAAAAATCCTCAAAATTTACAA
CCTGTTCCTGCTAACCTTGTGAACCGAGTTCAATCATTAGTCGCTGATGTCGATGTATCTCTGGATGAGCCTTTAGCCGA
CGAGGATGAGTAG

Structures

Antitoxin

• AlphaFold DB: U2M6Q5