Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4374755..4375411 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4J950
Locus tag KGP21_RS20865 Protein ID WP_021807143.1
Coordinates 4374755..4375144 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2NVJ4
Locus tag KGP21_RS20870 Protein ID WP_021178792.1
Coordinates 4375148..4375411 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS20850 (KGP21_20775) 4371210..4372655 + 1446 WP_021807140.1 MFS transporter -
KGP21_RS20855 (KGP21_20780) 4372652..4374022 + 1371 WP_218519040.1 two-component system sensor histidine kinase BaeS -
KGP21_RS20860 (KGP21_20785) 4374035..4374751 + 717 WP_021807142.1 two-component system response regulator BaeR -
KGP21_RS20865 (KGP21_20790) 4374755..4375144 - 390 WP_021807143.1 type II toxin-antitoxin system VapC family toxin Toxin
KGP21_RS20870 (KGP21_20795) 4375148..4375411 - 264 WP_021178792.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP21_RS20875 (KGP21_20800) 4375758..4376096 + 339 WP_021178793.1 YegP family protein -
KGP21_RS20880 (KGP21_20805) 4376277..4377629 + 1353 WP_021178794.1 tRNA 5-hydroxyuridine modification protein YegQ -
KGP21_RS20885 (KGP21_20810) 4378166..4379065 + 900 WP_059201495.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14260.54 Da        Isoelectric Point: 7.8799

>T201593 WP_021807143.1 NZ_CP074140:c4375144-4374755 [Serratia sp. JSRIV004]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Download         Length: 390 bp

>T201593 NZ_CP098611:c1095075-1094821 [Phormidium yuhuli AB48]
ATGAAGACGACGTTTTCTGAGTCAGCCTGGGATGATTACCTCTACTGGCAAAAAATGGACAAAAAAATCCTGCGTCGGGT
GAACCAACTGATTAAAGAGATTCATCGCACGCCTTTCGAGGGGATTGGTAAACCTGAGCCACTCAAACATAATCTTGCCG
GATATTGGTCTCGACGAATCACCGCTGAACAGCGAATGGTGTACAAAGTCACCCCAGACGAGCTTATGATTGCTCAGCTT
CGCTATCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10157.53 Da        Isoelectric Point: 4.8232

>AT201593 WP_021178792.1 NZ_CP074140:c4375411-4375148 [Serratia sp. JSRIV004]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Download         Length: 264 bp

>AT201593 NZ_CP098611:c1095323-1095072 [Phormidium yuhuli AB48]
ATGGATGCCCTCAGCTACACCGCCGCTAGAAGGAATCTAGCCAAAACAATGCAGCAAGTCTGTGAGGATCACTCCCCCGT
CATCATCACCCGAAATAAAGCGGCTTCGGTGGTGATGATGTCCCTAGAGGATTACGAAGCCTTGCAAGAAACCGCCTACC
TGTTGCGTAGTCCAGCCAACGCCCGCCGTCTCTTAGAGTCTATTGCAGAACTTGAACAAGGTGGCGGCCAGGAACGAGAA
CTTTTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4J950

Antitoxin

Source ID Structure
AlphaFold DB U2NVJ4

References