Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1650015..1650663 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Y8XHQ9
Locus tag KGP21_RS07760 Protein ID WP_039995750.1
Coordinates 1650460..1650663 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U2LL75
Locus tag KGP21_RS07755 Protein ID WP_021180099.1
Coordinates 1650015..1650422 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS07740 (KGP21_07700) 1645386..1645865 - 480 WP_021805445.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
KGP21_RS07745 (KGP21_07705) 1646087..1646890 - 804 WP_021805444.1 TraB/GumN family protein -
KGP21_RS07750 (KGP21_07710) 1647040..1649751 - 2712 WP_223537737.1 copper-exporting P-type ATPase CopA -
KGP21_RS07755 (KGP21_07715) 1650015..1650422 - 408 WP_021180099.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KGP21_RS07760 (KGP21_07720) 1650460..1650663 - 204 WP_039995750.1 type II toxin-antitoxin system HicA family toxin Toxin
KGP21_RS07765 (KGP21_07725) 1650888..1651289 + 402 WP_094981176.1 Cu(I)-responsive transcriptional regulator -
KGP21_RS07770 (KGP21_07730) 1651286..1651744 - 459 WP_223500987.1 NfeD family protein -
KGP21_RS07775 (KGP21_07735) 1651747..1652652 - 906 WP_223537740.1 SPFH domain-containing protein -
KGP21_RS07780 (KGP21_07740) 1652836..1653759 - 924 WP_021180095.1 HTH-type transcriptional activator AllS -
KGP21_RS07785 (KGP21_07745) 1654112..1654603 + 492 WP_209528403.1 ureidoglycolate lyase -
KGP21_RS07790 (KGP21_07750) 1654672..1655487 + 816 WP_021805438.1 HTH-type transcriptional repressor AllR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7360.79 Da        Isoelectric Point: 11.5784

>T201583 WP_039995750.1 NZ_CP074140:c1650663-1650460 [Serratia sp. JSRIV004]
MESGELIKRLQADGWIIRKSRGKKATGSHVTMTKPGVAKIITIPHPKKDSSKGILRQVQQISGLKLI

Download         Length: 204 bp

>T201583 NZ_CP098604:c2347982-2347701 [Xanthomonas hortorum pv. pelargonii]
ATGATCAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGTTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GCCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGTATTCCACCTGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAATGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTTGCCGAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15337.37 Da        Isoelectric Point: 4.4886

>AT201583 WP_021180099.1 NZ_CP074140:c1650422-1650015 [Serratia sp. JSRIV004]
MIYPIFIFKTSEGFDGYFPDVEGCFFAGEKMSDIPKNAEEAFGVHMEALIEEGFPVPAAPQDPQSYLNDSRLREDGGILG
FVEIDPAKYEDKSIKFNLTMPRNLLTAIDKYIETTRGYKNRSQFLAELAREKISH

Download         Length: 408 bp

>AT201583 NZ_CP098604:c2347683-2347393 [Xanthomonas hortorum pv. pelargonii]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATCCTGCTCGAAGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCCACCGCCGTGCCGCCGCGCCGCATCAACGAGATCGTGCTGGGCAAGCGTGGCATCACCGCCGACACCG
CCGTGCGCCTGGCTGCAGCGTTGGGCACGACCGAGCGGTTCTGGCTGGGCCTGCAGGCCGATTACGAACTGGAACAAGCG
CACCGCGCGCTGGGCGACCTGCCGTCGCGGATCAAGCGGCTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8XHQ9

Antitoxin

Source ID Structure
AlphaFold DB U2LL75

References