Detailed information of TA system TA201580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 793914..794476
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A0F7HBD7
• Locus tag: KGP21_RS03720
• Protein ID: WP_024486364.1
• Coordinates: 793914..794231 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: KGP21_RS03725
• Protein ID: WP_218519922.1
• Coordinates: 794231..794476 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS03705 (KGP21_03685)	789611..790705	+	1095	WP_021807814.1	LPS export ABC transporter permease LptF	-
KGP21_RS03710 (KGP21_03690)	790705..791775	+	1071	WP_021807815.1	LPS export ABC transporter permease LptG	-
KGP21_RS03715 (KGP21_03695)	791877..793673	-	1797	WP_223537235.1	glycosyl hydrolase family 28 protein	-
KGP21_RS03720 (KGP21_03700)	793914..794231	-	318	WP_024486364.1	CcdB family protein	Toxin
KGP21_RS03725 (KGP21_03705)	794231..794476	-	246	WP_218519922.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
KGP21_RS03730 (KGP21_03710)	794566..794895	-	330	WP_021179117.1	multidrug efflux SMR transporter	-
KGP21_RS03735 (KGP21_03715)	794907..795266	-	360	WP_021179118.1	multidrug efflux SMR transporter	-
KGP21_RS03740 (KGP21_03720)	795321..795989	-	669	WP_223537237.1	hypothetical protein	-
KGP21_RS03745 (KGP21_03725)	796000..796635	-	636	WP_094982215.1	phosphate propanoyltransferase	-
KGP21_RS03750 (KGP21_03730)	796671..797105	-	435	WP_223537240.1	BMC domain-containing protein	-
KGP21_RS03755 (KGP21_03735)	797116..798066	-	951	WP_021807820.1	choline TMA-lyase-activating enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (3-104)

Antitoxin

• Post-segregation antitoxin CcdA (9-75)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11652.62 Da
• Isoelectric Point: 8.0501

>T201580 WP_024486364.1 NZ_CP074140:c794231-793914 [Serratia sp. JSRIV004]
MKQFSVYKNQSKNKKAYPFFIVVQSDLLDHLSTRLVMPLALKHATNSQVKALTPVLSVDQQDYVILTSLLTTTDVKNLNA
DCLVTNAAHLRDELVAAIDLLVLGI

Nucleotide

• Length: 318 bp

>T201580 NZ_CP074140:c794231-793914 [Serratia sp. JSRIV004]
ATGAAACAATTTTCTGTTTATAAAAATCAATCTAAAAACAAAAAAGCCTATCCTTTCTTTATCGTTGTTCAGTCCGATTT
ACTCGATCACCTTAGCACTCGTTTGGTCATGCCCTTGGCTTTAAAGCATGCAACAAACTCACAGGTCAAAGCACTGACTC
CTGTTTTGTCTGTGGATCAACAAGATTACGTGATCCTTACTAGTTTACTGACGACTACGGATGTCAAAAATCTTAATGCA
GATTGCCTAGTTACCAATGCAGCCCATCTGCGTGATGAGCTGGTTGCGGCCATCGACCTGTTAGTTTTGGGCATTTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8902.14 Da
• Isoelectric Point: 5.0644

>AT201580 WP_218519922.1 NZ_CP074140:c794476-794231 [Serratia sp. JSRIV004]
MGTVSVIKKRNTNVYLSVDLIEKAKALDLNLSATLNHALELAVKKGQRERWLAENRAGLEALNGFVEENGLFSDDADFGV
L

Nucleotide

• Length: 246 bp

>AT201580 NZ_CP074140:c794476-794231 [Serratia sp. JSRIV004]
ATGGGAACCGTTTCAGTAATAAAAAAGCGCAATACTAACGTGTACTTAAGTGTCGACCTGATCGAAAAGGCTAAAGCATT
AGACCTAAACTTATCGGCTACACTAAACCACGCATTAGAACTCGCAGTGAAGAAGGGGCAACGTGAACGTTGGTTAGCGG
AAAATCGTGCTGGTCTTGAAGCATTGAATGGCTTCGTTGAGGAGAACGGCCTTTTTTCTGATGATGCTGACTTTGGTGTC
CTGTAA

Structures

Toxin

• AlphaFold DB: A0A0F7HBD7