Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 718952..719734 Replicon chromosome
Accession NZ_CP074140
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP21_RS03360 Protein ID WP_223497969.1
Coordinates 719399..719734 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KGP21_RS03355 Protein ID WP_223497970.1
Coordinates 718952..719320 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS03330 (KGP21_03310) 714302..715063 + 762 WP_223537227.1 tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE -
KGP21_RS03335 (KGP21_03315) 715069..716676 - 1608 WP_223537229.1 GMC family oxidoreductase N-terminal domain-containing protein -
KGP21_RS03340 (KGP21_03320) 717265..717576 - 312 WP_223497973.1 putative addiction module antidote protein -
KGP21_RS03345 (KGP21_03325) 717617..717898 - 282 WP_223497972.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP21_RS03350 (KGP21_03330) 718019..718876 - 858 WP_223497971.1 DUF4942 domain-containing protein -
KGP21_RS03355 (KGP21_03335) 718952..719320 - 369 WP_223497970.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP21_RS03360 (KGP21_03340) 719399..719734 - 336 WP_223497969.1 TA system toxin CbtA family protein Toxin
KGP21_RS03365 (KGP21_03345) 719747..720229 - 483 WP_223497968.1 hypothetical protein -
KGP21_RS03370 (KGP21_03350) 720291..720611 - 321 WP_223497967.1 DUF5983 family protein -
KGP21_RS03375 (KGP21_03355) 720608..720985 - 378 WP_223497966.1 hypothetical protein -
KGP21_RS03380 (KGP21_03360) 721024..721512 - 489 WP_223497965.1 DNA repair protein RadC -
KGP21_RS03385 (KGP21_03365) 721527..721979 - 453 Protein_648 antirestriction protein -
KGP21_RS03390 (KGP21_03370) 722098..722346 - 249 WP_223497964.1 hypothetical protein -
KGP21_RS03395 (KGP21_03375) 722346..723170 - 825 WP_223497963.1 DUF932 domain-containing protein -
KGP21_RS03400 (KGP21_03380) 723342..723581 - 240 WP_223497962.1 hypothetical protein -
KGP21_RS03405 (KGP21_03385) 723584..723802 - 219 WP_223497961.1 hypothetical protein -
KGP21_RS03410 (KGP21_03390) 723865..724569 - 705 WP_223497960.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(20-103)

Antitoxin

Antitoxin CbeA

(17-115)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12501.29 Da        Isoelectric Point: 6.6384

>T201579 WP_223497969.1 NZ_CP074140:c719734-719399 [Serratia sp. JSRIV004]
MKTINKLPHTPTHANPTFIEYQQLLAWLLGHCYGLELNDTPYHDDQAIAQQIEHGITVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLSGGDLLRARSALGLRSPAIRRLA

Download         Length: 336 bp

>T201579 NZ_CP098604:1089815-1090072 [Xanthomonas hortorum pv. pelargonii]
GTGATTCTGCAGTTTGCTGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATTGTCTACAAGGCCGAGAACGGTATCCTGCTGATTGCTCAGGCG
CGCTACCACTACGCGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13401.97 Da        Isoelectric Point: 6.3645

>AT201579 WP_223497970.1 NZ_CP074140:c719320-718952 [Serratia sp. JSRIV004]
MKDSDTDNHEDSTPSPIWGLHCAITPRLGARLVQQGNRLHFLVDRAGLVGTFSPNDLKGLNSAFPVLIEQLETCLRSGEL
DQRRQHCVTVQHAGFTCQADTLGSFGHVYIAVYQTAQHTSGE

Download         Length: 369 bp

>AT201579 NZ_CP098604:1089567-1089818 [Xanthomonas hortorum pv. pelargonii]
ATGGACACCATCACTTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCATGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTAGTCATGTTGTCGCTGGAAGACTACAAGGCCATGGAAGAGACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References