Detailed information of TA system TA201578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 684249..684820
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP21_RS03215
• Protein ID: WP_059199563.1
• Coordinates: 684545..684820 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2NJB3
• Locus tag: KGP21_RS03210
• Protein ID: WP_021179086.1
• Coordinates: 684249..684536 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS03180 (KGP21_03160)	679477..680265	-	789	WP_223537206.1	phosphonate C-P lyase system protein PhnK	-
KGP21_RS03185 (KGP21_03165)	680265..681116	-	852	WP_059199559.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
KGP21_RS03190 (KGP21_03170)	681109..682194	-	1086	WP_094981873.1	carbon-phosphorus lyase complex subunit PhnI	-
KGP21_RS03195 (KGP21_03175)	682194..682775	-	582	WP_021807489.1	phosphonate C-P lyase system protein PhnH	-
KGP21_RS03200 (KGP21_03180)	682779..683222	-	444	WP_179248704.1	phosphonate C-P lyase system protein PhnG	-
KGP21_RS03205 (KGP21_03185)	683223..683951	-	729	WP_223498790.1	phosphonate metabolism transcriptional regulator PhnF	-
KGP21_RS03210 (KGP21_03190)	684249..684536	+	288	WP_021179086.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KGP21_RS03215 (KGP21_03195)	684545..684820	+	276	WP_059199563.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP21_RS03220 (KGP21_03200)	684817..685281	-	465	WP_021807485.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KGP21_RS03225 (KGP21_03205)	685559..687697	-	2139	WP_021807484.1	anaerobic ribonucleoside-triphosphate reductase	-
KGP21_RS03230 (KGP21_03210)	688009..688896	-	888	WP_037376526.1	LysR family transcriptional regulator	-
KGP21_RS03235 (KGP21_03215)	689001..689525	+	525	WP_059199567.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10613.23 Da
• Isoelectric Point: 4.2503

>T201578 WP_059199563.1 NZ_CP074140:684545-684820 [Serratia sp. JSRIV004]
MRIEWDDVALQDRERIFEFLYPLNSLAAEQVDDEIELAVESLLENPEMGRPWYGEARKLVISKASLLLIYVILDEVIKVL
AVAHQREKFPN

Nucleotide

• Length: 276 bp

>T201578 NZ_CP098604:1089567-1089818 [Xanthomonas hortorum pv. pelargonii]
ATGGACACCATCACTTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCATGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTAGTCATGTTGTCGCTGGAAGACTACAAGGCCATGGAAGAGACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.35 Da
• Isoelectric Point: 8.0314

>AT201578 WP_021179086.1 NZ_CP074140:684249-684536 [Serratia sp. JSRIV004]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKAKVRAKYATK

Nucleotide

• Length: 288 bp

>AT201578 NZ_CP098604:1089815-1090072 [Xanthomonas hortorum pv. pelargonii]
GTGATTCTGCAGTTTGCTGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATTGTCTACAAGGCCGAGAACGGTATCCTGCTGATTGCTCAGGCG
CGCTACCACTACGCGTAA

Structures

Antitoxin

• AlphaFold DB: U2NJB3