Detailed information of TA system TA201575

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 169128..169911
• Replicon: chromosome
• Accession: NZ_CP074140
• Organism: Serratia sp. JSRIV004

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: KGP21_RS00725
• Protein ID: WP_223536916.1
• Coordinates: 169128..169460 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KGP21_RS00730
• Protein ID: WP_223536919.1
• Coordinates: 169537..169911 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP21_RS00685 (KGP21_00675)	164162..164770	-	609	WP_223536898.1	hypothetical protein	-
KGP21_RS00690 (KGP21_00680)	165206..166093	+	888	WP_223536901.1	50S ribosome-binding GTPase	-
KGP21_RS00695 (KGP21_00685)	166156..166626	+	471	WP_223536903.1	hypothetical protein	-
KGP21_RS00700 (KGP21_00690)	166758..167114	+	357	WP_223536905.1	hypothetical protein	-
KGP21_RS00705 (KGP21_00695)	167304..167741	+	438	WP_223536907.1	antirestriction protein	-
KGP21_RS00710 (KGP21_00700)	167760..168248	+	489	WP_223536909.1	DNA repair protein RadC	-
KGP21_RS00715 (KGP21_00705)	168242..168574	+	333	WP_223536911.1	DUF5983 family protein	-
KGP21_RS00720 (KGP21_00710)	168637..169122	+	486	WP_223536913.1	hypothetical protein	-
KGP21_RS00725 (KGP21_00715)	169128..169460	+	333	WP_223536916.1	TA system toxin CbtA family protein	Toxin
KGP21_RS00730 (KGP21_00720)	169537..169911	+	375	WP_223536919.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KGP21_RS00735 (KGP21_00725)	169999..170856	+	858	WP_223536922.1	DUF4942 domain-containing protein	-
KGP21_RS00740 (KGP21_00730)	171342..172460	+	1119	WP_223536926.1	PIN domain-containing protein	-
KGP21_RS00745 (KGP21_00735)	172576..173736	-	1161	WP_223536928.1	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	122727..180611	57884
	-	flank	IS/Tn	-	-	172576..173736	1160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (18-104)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12396.40 Da
• Isoelectric Point: 7.2753

>T201575 WP_223536916.1 NZ_CP074140:169128-169460 [Serratia sp. JSRIV004]
MKAIDKVLHTAPKKPALIEYQQLLAWLLDHCYGLTLNDTPYHDPLAIAQQIEYGVTVRETINELVQKFDLVRVDRPGFSL
LAQDPTLSGSDMLRVRSALGLRTPINSRLV

Nucleotide

• Length: 333 bp

>T201575 NZ_CP098548:651615-652034 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGTGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13432.41 Da
• Isoelectric Point: 6.0609

>AT201575 WP_223536919.1 NZ_CP074140:169537-169911 [Serratia sp. JSRIV004]
MVKIPDPKAPNNIPDPTPFWGLQPDITPRLGARLVQQGAHLHFLSDRAGCVGAFSPEAIQALELAFPVLVETLETLLRSG
ELGPRRQHCVAVQHAGFTCEADTLGSFGYVYIAVYQTARPPVAE

Nucleotide

• Length: 375 bp

>AT201575 NZ_CP098548:651379-651615 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA