Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE(toxin)
Location 5011911..5012433 Replicon chromosome
Accession NZ_CP074137
Organism Serratia sp. JSRIV006

Toxin (Protein)


Gene name relE Uniprot ID A0A0U4JRE1
Locus tag KGP16_RS23130 Protein ID WP_021806920.1
Coordinates 5012152..5012433 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U4HY11
Locus tag KGP16_RS23125 Protein ID WP_021806919.1
Coordinates 5011911..5012162 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP16_RS23100 (KGP16_23030) 5007460..5008269 - 810 WP_223500414.1 SDR family oxidoreductase -
KGP16_RS23105 (KGP16_23035) 5008266..5008922 - 657 WP_021180630.1 iron-containing redox enzyme family protein -
KGP16_RS23110 (KGP16_23040) 5008919..5010358 - 1440 WP_094983167.1 AMP-dependent synthetase/ligase -
KGP16_RS23115 (KGP16_23045) 5010355..5010999 - 645 WP_021806917.1 thermostable hemolysin -
KGP16_RS23120 (KGP16_23050) 5011193..5011846 + 654 WP_021806918.1 Qnr family pentapeptide repeat protein -
KGP16_RS23125 (KGP16_23055) 5011911..5012162 + 252 WP_021806919.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KGP16_RS23130 (KGP16_23060) 5012152..5012433 + 282 WP_021806920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP16_RS23135 (KGP16_23065) 5012602..5013237 + 636 WP_218520259.1 glutathione transferase -
KGP16_RS23140 (KGP16_23070) 5013348..5014802 - 1455 WP_021180637.1 NAD-dependent succinate-semialdehyde dehydrogenase -
KGP16_RS23145 (KGP16_23075) 5014815..5016080 - 1266 WP_166733462.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10991.89 Da        Isoelectric Point: 10.6704

>T201571 WP_021806920.1 NZ_CP074137:5012152-5012433 [Serratia sp. JSRIV006]
MTYKLKFEKRALKEWEKLGYPVREQLKKKLAERLENPHVPASRLSGRPNRYKIKLRSSGYRLVYEVRDNEIVLLVIAVGK
RAGEEVYFAADKR

Download         Length: 282 bp

>T201571 NZ_CP098545:36-314 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9243.37 Da        Isoelectric Point: 3.7947

>AT201571 WP_021806919.1 NZ_CP074137:5011911-5012162 [Serratia sp. JSRIV006]
MAFQILTTIAASITDLKKNPMGTVADGEGEAVAILNRNEPAFYCVPPELYAYYRELAEDAELNRIADERMEDAEFVSVDL
NDL

Download         Length: 252 bp

>AT201571 NZ_CP098545:4004-36 [Neisseria gonorrhoeae]

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4JRE1

Antitoxin

Source ID Structure
AlphaFold DB A0A0U4HY11

References