Detailed information of TA system TA201570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4854278..4854834
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP16_RS22500
• Protein ID: WP_024531262.1
• Coordinates: 4854559..4854834 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KGP16_RS22495
• Protein ID: WP_024531263.1
• Coordinates: 4854278..4854559 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS22450 (KGP16_22380)	4849833..4850081	+	249	WP_024531272.1	hypothetical protein	-
KGP16_RS22455 (KGP16_22385)	4850206..4850652	+	447	WP_024531271.1	antirestriction protein	-
KGP16_RS22460 (KGP16_22390)	4850663..4851148	+	486	WP_024531270.1	DNA repair protein RadC	-
KGP16_RS22465 (KGP16_22395)	4851183..4851557	+	375	WP_024531269.1	hypothetical protein	-
KGP16_RS22470 (KGP16_22400)	4851557..4851874	+	318	WP_024531268.1	DUF5983 family protein	-
KGP16_RS22475 (KGP16_22405)	4851937..4852422	+	486	WP_024531267.1	hypothetical protein	-
KGP16_RS22480 (KGP16_22410)	4852436..4852771	+	336	WP_051372474.1	TA system toxin CbtA family protein	-
KGP16_RS22485 (KGP16_22415)	4852851..4853237	+	387	WP_024531265.1	type IV toxin-antitoxin system YeeU family antitoxin	-
KGP16_RS22490 (KGP16_22420)	4853314..4854171	+	858	WP_024531264.1	DUF4942 domain-containing protein	-
KGP16_RS22495 (KGP16_22425)	4854278..4854559	+	282	WP_024531263.1	ribbon-helix-helix domain-containing protein	Antitoxin
KGP16_RS22500 (KGP16_22430)	4854559..4854834	+	276	WP_024531262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP16_RS22505 (KGP16_22435)	4855116..4856228	-	1113	WP_223500374.1	M20 family metallopeptidase	-
KGP16_RS22510 (KGP16_22440)	4856325..4856786	-	462	WP_115159346.1	YjiG family protein	-
KGP16_RS22515 (KGP16_22445)	4856803..4857537	-	735	WP_155621780.1	nucleoside recognition domain-containing protein	-
KGP16_RS22520 (KGP16_22450)	4858069..4858872	-	804	WP_223500375.1	histidine phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10680.34 Da
• Isoelectric Point: 8.5522

>T201570 WP_024531262.1 NZ_CP074137:4854559-4854834 [Serratia sp. JSRIV006]
MQVVWSDHALQDLERLREFIANVNPEAAAQVLQSLVLAPANLLTHSRMGPALARYEPREVRRLIVGNYEMHYELKVNALY
MLRVWHTRENR

Nucleotide

• Length: 276 bp

>T201570 NZ_CP098544:c1017119-1016700 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10324.74 Da
• Isoelectric Point: 4.7628

>AT201570 WP_024531263.1 NZ_CP074137:4854278-4854559 [Serratia sp. JSRIV006]
MGQSVTRVITAHIPVEMAEKIDELAANYDRSRGWIVKQALAAIIEQEESRHYMILQGLADVDAGRVVEQADVLKWVNSLN
NDTPLPVPQSGQK

Nucleotide

• Length: 282 bp

>AT201570 NZ_CP098544:c1017355-1017119 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA