Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 4852436..4853237 Replicon chromosome
Accession NZ_CP074137
Organism Serratia sp. JSRIV006

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KGP16_RS22480 Protein ID WP_051372474.1
Coordinates 4852436..4852771 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KGP16_RS22485 Protein ID WP_024531265.1
Coordinates 4852851..4853237 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP16_RS22435 (KGP16_22365) 4847986..4848438 + 453 WP_024531275.1 hypothetical protein -
KGP16_RS22440 (KGP16_22370) 4848435..4848887 + 453 WP_024531274.1 IrmA family protein -
KGP16_RS22445 (KGP16_22375) 4849009..4849833 + 825 WP_024531273.1 DUF932 domain-containing protein -
KGP16_RS22450 (KGP16_22380) 4849833..4850081 + 249 WP_024531272.1 hypothetical protein -
KGP16_RS22455 (KGP16_22385) 4850206..4850652 + 447 WP_024531271.1 antirestriction protein -
KGP16_RS22460 (KGP16_22390) 4850663..4851148 + 486 WP_024531270.1 DNA repair protein RadC -
KGP16_RS22465 (KGP16_22395) 4851183..4851557 + 375 WP_024531269.1 hypothetical protein -
KGP16_RS22470 (KGP16_22400) 4851557..4851874 + 318 WP_024531268.1 DUF5983 family protein -
KGP16_RS22475 (KGP16_22405) 4851937..4852422 + 486 WP_024531267.1 hypothetical protein -
KGP16_RS22480 (KGP16_22410) 4852436..4852771 + 336 WP_051372474.1 TA system toxin CbtA family protein Toxin
KGP16_RS22485 (KGP16_22415) 4852851..4853237 + 387 WP_024531265.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KGP16_RS22490 (KGP16_22420) 4853314..4854171 + 858 WP_024531264.1 DUF4942 domain-containing protein -
KGP16_RS22495 (KGP16_22425) 4854278..4854559 + 282 WP_024531263.1 ribbon-helix-helix domain-containing protein -
KGP16_RS22500 (KGP16_22430) 4854559..4854834 + 276 WP_024531262.1 type II toxin-antitoxin system RelE/ParE family toxin -
KGP16_RS22505 (KGP16_22435) 4855116..4856228 - 1113 WP_223500374.1 M20 family metallopeptidase -
KGP16_RS22510 (KGP16_22440) 4856325..4856786 - 462 WP_115159346.1 YjiG family protein -
KGP16_RS22515 (KGP16_22445) 4856803..4857537 - 735 WP_155621780.1 nucleoside recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(10-102)

Antitoxin

Antitoxin CbeA

(23-120)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12488.32 Da        Isoelectric Point: 5.5873

>T201569 WP_051372474.1 NZ_CP074137:4852436-4852771 [Serratia sp. JSRIV006]
MTMINTATPIAANARQALAEYQQLLTWLLGHCYGLELNDTPYHDDQAIIQQIEHGITVRETVNELVEKFDLVRIDRPGFS
LMAQDPTLNGGDMLRARSALGLRSPIIRRLT

Download         Length: 336 bp

>T201569 NZ_CP098544:c533963-533781 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGTCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 13961.50 Da        Isoelectric Point: 4.6598

>AT201569 WP_024531265.1 NZ_CP074137:4852851-4853237 [Serratia sp. JSRIV006]
MKEPITDNHTAPLTDDNSTPSTTWGLQSAITPRLGARLVQQGDRLHFLADRAGLLGTFSPDDLKALDEAFPVLIEQLEAC
LRSGELDQRRQQSVTLQHAGFSCEADTLGSFGHVYIAIYHATQSPGNE

Download         Length: 387 bp

>AT201569 NZ_CP098544:c533679-533278 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References