Detailed information of TA system TA201568

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4572124..4572793
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8H9YD80
• Locus tag: KGP16_RS21155
• Protein ID: WP_071681918.1
• Coordinates: 4572124..4572546 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: U2M6Q5
• Locus tag: KGP16_RS21160
• Protein ID: WP_021179805.1
• Coordinates: 4572527..4572793 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS21135 (KGP16_21075)	4567968..4568486	+	519	WP_021179810.1	flavodoxin FldB	-
KGP16_RS21140 (KGP16_21080)	4568522..4569910	-	1389	WP_223500291.1	cell envelope integrity protein CreD	-
KGP16_RS21145 (KGP16_21085)	4570014..4571432	-	1419	WP_021806194.1	two-component system sensor histidine kinase CreC	-
KGP16_RS21150 (KGP16_21090)	4571429..4572124	-	696	WP_021806195.1	two-component system response regulator CreB	-
KGP16_RS21155 (KGP16_21095)	4572124..4572546	-	423	WP_071681918.1	protein YgfX	Toxin
KGP16_RS21160 (KGP16_21100)	4572527..4572793	-	267	WP_021179805.1	FAD assembly factor SdhE	Antitoxin
KGP16_RS21165 (KGP16_21105)	4573094..4574086	+	993	WP_223501552.1	tRNA-modifying protein YgfZ	-
KGP16_RS21170 (KGP16_21110)	4574126..4574623	-	498	WP_021806198.1	DUF2165 domain-containing protein	-
KGP16_RS21175 (KGP16_21115)	4574855..4575529	-	675	WP_037375710.1	hemolysin III family protein	-
KGP16_RS21180 (KGP16_21120)	4575766..4576374	+	609	WP_094981477.1	HD domain-containing protein	-
KGP16_RS21185 (KGP16_21125)	4576408..4577154	-	747	WP_115159283.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16523.49 Da
• Isoelectric Point: 10.6373

>T201568 WP_071681918.1 NZ_CP074137:c4572546-4572124 [Serratia sp. JSRIV006]
VALWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGR
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLLFEQSATDEDV

Nucleotide

• Length: 423 bp

>T201568 NZ_CP098543:1334-1612 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10363.93 Da
• Isoelectric Point: 5.5847

>AT201568 WP_021179805.1 NZ_CP074137:c4572793-4572527 [Serratia sp. JSRIV006]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT201568 NZ_CP098543:1149-1334 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Structures

Antitoxin

• AlphaFold DB: U2M6Q5