Detailed information of TA system TA201567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 4390945..4391588
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: KGP16_RS20375
• Protein ID: WP_223498271.1
• Coordinates: 4390945..4391361 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: KGP16_RS20380
• Protein ID: WP_223498272.1
• Coordinates: 4391358..4391588 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS20360 (KGP16_20300)	4386947..4388443	+	1497	WP_235050830.1	multidrug efflux MFS transporter permease subunit EmrB	-
KGP16_RS20365 (KGP16_20305)	4388723..4388968	-	246	WP_223500255.1	hypothetical protein	-
KGP16_RS20370 (KGP16_20310)	4389290..4390732	-	1443	WP_223500066.1	IS1182 family transposase	-
KGP16_RS20375 (KGP16_20315)	4390945..4391361	-	417	WP_223498271.1	PIN domain-containing protein	Toxin
KGP16_RS20380 (KGP16_20320)	4391358..4391588	-	231	WP_223498272.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KGP16_RS20385 (KGP16_20325)	4391836..4392927	-	1092	WP_223500256.1	tRNA/rRNA methyltransferase	-
KGP16_RS20390 (KGP16_20330)	4393124..4393543	+	420	WP_094981235.1	thioredoxin TrxC	-
KGP16_RS20395 (KGP16_20335)	4393660..4394364	+	705	WP_021807596.1	tRNA-uridine aminocarboxypropyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4389290..4390732	1442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15130.47 Da
• Isoelectric Point: 7.7809

>T201567 WP_223498271.1 NZ_CP074137:c4391361-4390945 [Serratia sp. JSRIV006]
MNKTYMLDTNICSFIMREQPEAVIRRLEQAVMRNHRIVVSAITYAEMCFGTIGKKASPRHARLVEAFCSRLDAVLAWDRA
AVDATTNIKATLAAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVTDLILEDWAK

Nucleotide

• Length: 417 bp

>T201567 NZ_CP098542:c1522408-1522226 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8831.91 Da
• Isoelectric Point: 4.3142

>AT201567 WP_223498272.1 NZ_CP074137:c4391588-4391358 [Serratia sp. JSRIV006]
MRIVSVFKNGNNRAIRLPRDMDFEGVSELEITREGDSIILRPVRPSWGSFLQEEKADADFMTEREEIVSDEGRFEL

Nucleotide

• Length: 231 bp

>AT201567 NZ_CP098542:c1522124-1521723 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG