Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4190169..4190825 Replicon chromosome
Accession NZ_CP074137
Organism Serratia sp. JSRIV006

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4J950
Locus tag KGP16_RS19405 Protein ID WP_021807143.1
Coordinates 4190169..4190558 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2NVJ4
Locus tag KGP16_RS19410 Protein ID WP_021178792.1
Coordinates 4190562..4190825 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP16_RS19390 (KGP16_19345) 4186624..4188069 + 1446 WP_223500210.1 MFS transporter -
KGP16_RS19395 (KGP16_19350) 4188066..4189436 + 1371 WP_059201492.1 two-component system sensor histidine kinase BaeS -
KGP16_RS19400 (KGP16_19355) 4189449..4190165 + 717 WP_021807142.1 two-component system response regulator BaeR -
KGP16_RS19405 (KGP16_19360) 4190169..4190558 - 390 WP_021807143.1 type II toxin-antitoxin system VapC family toxin Toxin
KGP16_RS19410 (KGP16_19365) 4190562..4190825 - 264 WP_021178792.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KGP16_RS19415 (KGP16_19370) 4191172..4191510 + 339 WP_021178793.1 YegP family protein -
KGP16_RS19420 (KGP16_19375) 4191691..4193043 + 1353 WP_021178794.1 tRNA 5-hydroxyuridine modification protein YegQ -
KGP16_RS19425 (KGP16_19380) 4193580..4194479 + 900 WP_223500211.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14260.54 Da        Isoelectric Point: 7.8799

>T201566 WP_021807143.1 NZ_CP074137:c4190558-4190169 [Serratia sp. JSRIV006]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGRPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Download         Length: 390 bp

>T201566 NZ_CP098542:652597-653016 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10157.53 Da        Isoelectric Point: 4.8232

>AT201566 WP_021178792.1 NZ_CP074137:c4190825-4190562 [Serratia sp. JSRIV006]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Download         Length: 264 bp

>AT201566 NZ_CP098542:652361-652597 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4J950

Antitoxin

Source ID Structure
AlphaFold DB U2NVJ4

References