Detailed information of TA system TA201556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1679570..1680327
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: KGP16_RS07770
• Protein ID: WP_179252390.1
• Coordinates: 1679570..1680052 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A448SFY1
• Locus tag: KGP16_RS07775
• Protein ID: WP_071683113.1
• Coordinates: 1680043..1680327 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS07745 (KGP16_07730)	1675490..1676227	+	738	WP_223501113.1	5-oxoprolinase subunit PxpA	-
KGP16_RS07750 (KGP16_07735)	1676294..1677025	+	732	WP_021805279.1	DUF969 domain-containing protein	-
KGP16_RS07755 (KGP16_07740)	1677022..1678029	+	1008	WP_021805278.1	DUF979 domain-containing protein	-
KGP16_RS07760 (KGP16_07745)	1678038..1678682	+	645	WP_179245125.1	pyroglutamyl-peptidase I	-
KGP16_RS07765 (KGP16_07750)	1678755..1679546	+	792	WP_223501114.1	endonuclease VIII	-
KGP16_RS07770 (KGP16_07755)	1679570..1680052	-	483	WP_179252390.1	GNAT family N-acetyltransferase	Toxin
KGP16_RS07775 (KGP16_07760)	1680043..1680327	-	285	WP_071683113.1	DUF1778 domain-containing protein	Antitoxin
KGP16_RS07780 (KGP16_07765)	1680716..1682005	-	1290	WP_021805275.1	citrate synthase	-
KGP16_RS07785 (KGP16_07770)	1682652..1683041	+	390	WP_024483149.1	succinate dehydrogenase cytochrome b556 subunit	-
KGP16_RS07790 (KGP16_07775)	1683035..1683382	+	348	WP_021805273.1	succinate dehydrogenase membrane anchor subunit	-
KGP16_RS07795 (KGP16_07780)	1683383..1685149	+	1767	WP_021805272.1	succinate dehydrogenase flavoprotein subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (25-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-93)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 18003.85 Da
• Isoelectric Point: 7.7995

>T201556 WP_179252390.1 NZ_CP074137:c1680052-1679570 [Serratia sp. JSRIV006]
MEIIITAPELLTEEHILQPFDCGNEVLSDWLRRRAMRNQLLNASRTFVICLEGTKRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPIVLLGRLAVDVCTQGHRFGKWLLNDAVRRVANLADQVGIKAIMVHAIDDQARAFYEYFGFVQSPIAANTLFYKI

Nucleotide

• Length: 483 bp

>T201556 NZ_CP098532:1207727-1207909 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11066.66 Da
• Isoelectric Point: 8.5275

>AT201556 WP_071683113.1 NZ_CP074137:c1680327-1680043 [Serratia sp. JSRIV006]
MQKTVRKPTRDKQINVRATEEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRKRLMDVKPEWK

Nucleotide

• Length: 285 bp

>AT201556 NZ_CP098532:1208011-1208412 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Antitoxin

• AlphaFold DB: A0A448SFY1