Detailed information of TA system TA201555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1425914..1426562
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KGP16_RS06430
• Protein ID: WP_094981177.1
• Coordinates: 1426359..1426562 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U2LL75
• Locus tag: KGP16_RS06425
• Protein ID: WP_021180099.1
• Coordinates: 1425914..1426321 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS06410 (KGP16_06400)	1421285..1421764	-	480	WP_094981179.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-
KGP16_RS06415 (KGP16_06405)	1421986..1422789	-	804	WP_071682995.1	TraB/GumN family protein	-
KGP16_RS06420 (KGP16_06410)	1422939..1425650	-	2712	WP_223500986.1	copper-exporting P-type ATPase CopA	-
KGP16_RS06425 (KGP16_06415)	1425914..1426321	-	408	WP_021180099.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KGP16_RS06430 (KGP16_06420)	1426359..1426562	-	204	WP_094981177.1	type II toxin-antitoxin system HicA family toxin	Toxin
KGP16_RS06435 (KGP16_06425)	1426787..1427188	+	402	WP_094981176.1	Cu(I)-responsive transcriptional regulator	-
KGP16_RS06440 (KGP16_06430)	1427185..1427643	-	459	WP_223500987.1	NfeD family protein	-
KGP16_RS06445 (KGP16_06435)	1427646..1428551	-	906	WP_021180096.1	SPFH domain-containing protein	-
KGP16_RS06450 (KGP16_06440)	1428735..1429658	-	924	WP_021180095.1	HTH-type transcriptional activator AllS	-
KGP16_RS06455 (KGP16_06445)	1430011..1430502	+	492	WP_059201975.1	ureidoglycolate lyase	-
KGP16_RS06460 (KGP16_06450)	1430572..1431387	+	816	WP_021805438.1	HTH-type transcriptional repressor AllR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7370.83 Da
• Isoelectric Point: 11.5784

>T201555 WP_094981177.1 NZ_CP074137:c1426562-1426359 [Serratia sp. JSRIV006]
MESGELIKRLQADGWIIRKSRGKKATGSHVTMTKPGVAKIITIPHPKKDPSKGILRQVQQISGLKLI

Nucleotide

• Length: 204 bp

>T201555 NZ_CP098532:724252-724671 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15337.37 Da
• Isoelectric Point: 4.4886

>AT201555 WP_021180099.1 NZ_CP074137:c1426321-1425914 [Serratia sp. JSRIV006]
MIYPIFIFKTSEGFDGYFPDVEGCFFAGEKMSDIPKNAEEAFGVHMEALIEEGFPVPAAPQDPQSYLNDSRLREDGGILG
FVEIDPAKYEDKSIKFNLTMPRNLLTAIDKYIETTRGYKNRSQFLAELAREKISH

Nucleotide

• Length: 408 bp

>AT201555 NZ_CP098532:724016-724252 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Antitoxin

• AlphaFold DB: U2LL75