Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1197601..1198157 Replicon chromosome
Accession NZ_CP074137
Organism Serratia sp. JSRIV006

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KGP16_RS05375 Protein ID WP_021805609.1
Coordinates 1197601..1197891 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2MX00
Locus tag KGP16_RS05380 Protein ID WP_021181943.1
Coordinates 1197879..1198157 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP16_RS05355 (KGP16_05345) 1192687..1193637 - 951 WP_094983017.1 GNAT family N-acetyltransferase -
KGP16_RS05360 (KGP16_05350) 1193634..1195364 - 1731 WP_223500923.1 IucA/IucC family protein -
KGP16_RS05365 (KGP16_05355) 1195498..1196724 + 1227 WP_223500925.1 MFS transporter -
KGP16_RS05370 (KGP16_05360) 1196726..1197604 + 879 WP_179249125.1 siderophore-interacting protein -
KGP16_RS05375 (KGP16_05365) 1197601..1197891 - 291 WP_021805609.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP16_RS05380 (KGP16_05370) 1197879..1198157 - 279 WP_021181943.1 CopG family ribbon-helix-helix protein Antitoxin
KGP16_RS05385 (KGP16_05375) 1198324..1199163 + 840 WP_021181942.1 MurR/RpiR family transcriptional regulator -
KGP16_RS05390 (KGP16_05380) 1199355..1200596 + 1242 WP_094983021.1 alanine--glyoxylate aminotransferase family protein -
KGP16_RS05395 (KGP16_05385) 1200596..1201915 + 1320 WP_094983022.1 allantoate amidohydrolase -
KGP16_RS05400 (KGP16_05390) 1201858..1202631 - 774 WP_021805606.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10910.59 Da        Isoelectric Point: 9.3939

>T201553 WP_021805609.1 NZ_CP074137:c1197891-1197601 [Serratia sp. JSRIV006]
VSQLKWSPAALADVQRLYLFLAEKDSDTAKRAISKIRRSVKILALQPQVGRPVEEMPHQYREWPIEFGSSGYVVLYHFDG
TVAVLLAVRHQLEAGY

Download         Length: 291 bp

>T201553 NZ_CP098521:3312595-3312774 [Acinetobacter baumannii]
ATGAGCTTCAACGAGTTTAAACGATGGCTAATTGCACAGGGAGTTATCTTTGTGCGTAAAGGTAAGGGATCACATATGAT
TATTGAATTTAACGGTAAGAAGACTGTTTTCCCTAACCACGGGAAAAAAGAAATTCCTGAAGGCACTCGTTTAAAGATCA
AAAAGGATTTGGGGCTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10862.10 Da        Isoelectric Point: 4.7997

>AT201553 WP_021181943.1 NZ_CP074137:c1198157-1197879 [Serratia sp. JSRIV006]
MATATSIKIDEELKLRVQQIALARQRTAHWIMREAIREYVEREEKREALRNDALRAWETYQADGKHLTQEEADNWLANLE
KGDDTEIPECHN

Download         Length: 279 bp

>AT201553 NZ_CP098521:3312860-3313273 [Acinetobacter baumannii]
ATGAAATGTTATGTCAGTATTCATAGGGAGGGAGAGGCTTTTATAGTCAGCTCAAGTGAACTCCCTGAACTAAATAGTGT
AGGCTATACTTTAGAAGAAGCTTTATCAGAAGCTTTGGATGGTATAGAAACAGTATTCGAAATTTATATGGATGAGCGTA
AAGCCATCCCATTACCATCAAAAGGTAAGAAAGGTGAATATGCAGTTCATCTTCCAGTTCGAGTCGCTGCTAAGGTACGT
TTATATAATGAGATGATCTCACAAAACGTTACTAAAGCTGAATTAGCTCGTCGCTTGGGGTGGTTACAGAAGCAAGCCGA
TCGTTTGCTTTCATTAAAGCATTCAACAAAACTAGAATCGATTGAAAGTGCCTTCCAAGCATTAGGCAAGGATCTCGATA
TAGTTATCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2MX00

References