Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 665625..666187 Replicon chromosome
Accession NZ_CP074137
Organism Serratia sp. JSRIV006

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag KGP16_RS03045 Protein ID WP_223500806.1
Coordinates 665625..665942 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag KGP16_RS03050 Protein ID WP_218519922.1
Coordinates 665942..666187 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP16_RS03030 (KGP16_03015) 661322..662416 + 1095 WP_065684324.1 LPS export ABC transporter permease LptF -
KGP16_RS03035 (KGP16_03020) 662416..663486 + 1071 WP_021807815.1 LPS export ABC transporter permease LptG -
KGP16_RS03040 (KGP16_03025) 663588..665384 - 1797 WP_223500805.1 glycosyl hydrolase family 28 protein -
KGP16_RS03045 (KGP16_03030) 665625..665942 - 318 WP_223500806.1 CcdB family protein Toxin
KGP16_RS03050 (KGP16_03035) 665942..666187 - 246 WP_218519922.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KGP16_RS03055 (KGP16_03040) 666277..666606 - 330 WP_021179117.1 multidrug efflux SMR transporter -
KGP16_RS03060 (KGP16_03045) 666618..666977 - 360 WP_223500807.1 multidrug efflux SMR transporter -
KGP16_RS03065 (KGP16_03050) 667032..667700 - 669 WP_223500808.1 hypothetical protein -
KGP16_RS03070 (KGP16_03055) 667711..668346 - 636 WP_094982215.1 phosphate propanoyltransferase -
KGP16_RS03075 (KGP16_03060) 668382..668816 - 435 WP_223500809.1 BMC domain-containing protein -
KGP16_RS03080 (KGP16_03065) 668827..669777 - 951 WP_021807820.1 choline TMA-lyase-activating enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(9-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11643.61 Da        Isoelectric Point: 8.0242

>T201551 WP_223500806.1 NZ_CP074137:c665942-665625 [Serratia sp. JSRIV006]
MKQFSVYKNQSKNKKAYPFFIVVQSDLLDHLSTRLVMPLALKQATNSQVKALTPVLSVDQQDYVILTSLLTTTDVKNLNA
DCLVTNAAHLRDELVAAIDLLVLGI

Download         Length: 318 bp

>T201551 NZ_CP098511:1535314-1535568 [Aquimarina sp. ERC-38]
ATGAAGTTAGTCTGGTCTACTTCTTCATGGGAAGATTATTTATACTGTCAGAAAACAAATAAAAGTACCATTAAAAGAAT
CAATCAACTCATTAAAAGTGCTTTAAGAACTCCTTTTGAAGGGATAGGGAAACCTGAAGCCTTAAAAGGTGATCTACAGG
GGTACTGGTCAAGACGTATAACTTCTGAACATAGATTGGTGTATAAATTCGAAGAGAATTCGTTGTTTATAGCATCTTGT
TGTTATCATTGTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8902.14 Da        Isoelectric Point: 5.0644

>AT201551 WP_218519922.1 NZ_CP074137:c666187-665942 [Serratia sp. JSRIV006]
MGTVSVIKKRNTNVYLSVDLIEKAKALDLNLSATLNHALELAVKKGQRERWLAENRAGLEALNGFVEENGLFSDDADFGV
L

Download         Length: 246 bp

>AT201551 NZ_CP098511:1535102-1535311 [Aquimarina sp. ERC-38]
ATGCTCTTAGATAAAGTGGTTGATGACGTAAGTGACATCGTTATTAAAAGAAAAGGAGGAAAAGACCTGGTCTTGATTTC
TTTAGAAGAATATAATTCATTAAAAGAGACCAATTATTTACTTACCGGAAAGAACAGGGACGTTTTGTTAGATTCAATTA
AAGAATTAGAAAATGGTAATGGGATTACAAAGAATATAAGTGATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References