Detailed information of TA system TA201550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 618896..619389
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGP16_RS02865
• Protein ID: WP_223500791.1
• Coordinates: 619192..619389 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2NJB3
• Locus tag: KGP16_RS02860
• Protein ID: WP_021179086.1
• Coordinates: 618896..619183 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS02830 (KGP16_02820)	614124..614912	-	789	WP_024483394.1	phosphonate C-P lyase system protein PhnK	-
KGP16_RS02835 (KGP16_02825)	614912..615763	-	852	WP_021807491.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
KGP16_RS02840 (KGP16_02830)	615756..616841	-	1086	WP_094981873.1	carbon-phosphorus lyase complex subunit PhnI	-
KGP16_RS02845 (KGP16_02835)	616826..617422	-	597	WP_223498789.1	phosphonate C-P lyase system protein PhnH	-
KGP16_RS02850 (KGP16_02840)	617426..617869	-	444	WP_179248704.1	phosphonate C-P lyase system protein PhnG	-
KGP16_RS02855 (KGP16_02845)	617870..618598	-	729	WP_021807487.1	phosphonate metabolism transcriptional regulator PhnF	-
KGP16_RS02860 (KGP16_02850)	618896..619183	+	288	WP_021179086.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KGP16_RS02865 (KGP16_02855)	619192..619389	+	198	WP_223500791.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP16_RS02870 (KGP16_02860)	619526..620002	+	477	WP_094981869.1	Hcp family type VI secretion system effector	-
KGP16_RS02875 (KGP16_02865)	620258..620965	-	708	WP_209529923.1	hypothetical protein	-
KGP16_RS02880	621440..621722	+	283	Protein_549	resolvase	-
KGP16_RS02885 (KGP16_02870)	621723..622187	-	465	WP_186486545.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-51)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-44)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7613.55 Da
• Isoelectric Point: 3.8209

>T201550 WP_223500791.1 NZ_CP074137:619192-619389 [Serratia sp. JSRIV006]
MRIEWDDVALQDRERIFEFLYPPNSLAAEQVDDEIELAVESLLENPEMVRLTSFVSAQLFNNKNI

Nucleotide

• Length: 198 bp

>T201550 NZ_CP098511:1535102-1535311 [Aquimarina sp. ERC-38]
ATGCTCTTAGATAAAGTGGTTGATGACGTAAGTGACATCGTTATTAAAAGAAAAGGAGGAAAAGACCTGGTCTTGATTTC
TTTAGAAGAATATAATTCATTAAAAGAGACCAATTATTTACTTACCGGAAAGAACAGGGACGTTTTGTTAGATTCAATTA
AAGAATTAGAAAATGGTAATGGGATTACAAAGAATATAAGTGATTTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10957.35 Da
• Isoelectric Point: 8.0314

>AT201550 WP_021179086.1 NZ_CP074137:618896-619183 [Serratia sp. JSRIV006]
MESRIQFRIENETKLLAQKAAEAKGTTLSEACRRLAQQMADDQRAAEEHENWLKDKVDAAFARLHEGEAVYLTQRQAEER
MSDFKAKVRAKYATK

Nucleotide

• Length: 288 bp

>AT201550 NZ_CP098511:1535314-1535568 [Aquimarina sp. ERC-38]
ATGAAGTTAGTCTGGTCTACTTCTTCATGGGAAGATTATTTATACTGTCAGAAAACAAATAAAAGTACCATTAAAAGAAT
CAATCAACTCATTAAAAGTGCTTTAAGAACTCCTTTTGAAGGGATAGGGAAACCTGAAGCCTTAAAAGGTGATCTACAGG
GGTACTGGTCAAGACGTATAACTTCTGAACATAGATTGGTGTATAAATTCGAAGAGAATTCGTTGTTTATAGCATCTTGT
TGTTATCATTGTTGA

Structures

Antitoxin

• AlphaFold DB: U2NJB3