Detailed information of TA system TA201549

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 554204..554751
• Replicon: chromosome
• Accession: NZ_CP074137
• Organism: Serratia sp. JSRIV006

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KGP16_RS02520
• Protein ID: WP_245398412.1
• Coordinates: 554473..554751 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7Y8XL57
• Locus tag: KGP16_RS02515
• Protein ID: WP_059201942.1
• Coordinates: 554204..554473 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGP16_RS02500 (KGP16_02490)	549260..553084	+	3825	WP_218519944.1	translocation/assembly module TamB domain-containing protein	-
KGP16_RS02505 (KGP16_02495)	553087..553437	+	351	WP_024483355.1	gamma-glutamylcyclotransferase	-
KGP16_RS02510 (KGP16_02500)	553488..554015	-	528	WP_021179028.1	inorganic diphosphatase	-
KGP16_RS02515 (KGP16_02505)	554204..554473	+	270	WP_059201942.1	hypothetical protein	Antitoxin
KGP16_RS02520 (KGP16_02510)	554473..554751	+	279	WP_245398412.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGP16_RS02525 (KGP16_02515)	554929..556482	+	1554	WP_059199539.1	methyl-accepting chemotaxis protein	-
KGP16_RS02530 (KGP16_02520)	556517..557521	-	1005	WP_021179030.1	class 1 fructose-bisphosphatase	-
KGP16_RS02535 (KGP16_02525)	557692..559071	+	1380	WP_024483358.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
KGP16_RS02540 (KGP16_02530)	559284..559547	-	264	WP_021179031.1	peroxide/acid stress response protein YhcN	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10984.56 Da
• Isoelectric Point: 6.4886

>T201549 WP_245398412.1 NZ_CP074137:554473-554751 [Serratia sp. JSRIV006]
MEIVWTQLASEDRRKIREYIAENNLRAAIELDERIGSMANSLAEHPLKGREGRVKETRELVIHPHFIEVYRVVNEWERIE
IIRVLHTAQQWP

Nucleotide

• Length: 279 bp

>T201549 NZ_CP098511:1366598-1366882 [Aquimarina sp. ERC-38]
ATGGAAACTTCAAAATTTGATATTGCAGATTATCTAGACAGTAAAGAAATGATTGTAGAATATCTTAATACTGTTCTGGA
AGAAGGTAATGATGCTGATATGGTTGTTGCTATTGGTCATGTTGCAAAAGCAATTGGAATGTCGAAAATTGCGGAGGAAA
CTGGGTTGAGTAGACCTAGTTTATACAAAGCTTTATCGGATGGGGCTAAACCTCAATTTGCAACTATTGTAAAAGTGTTA
AAAGCTATTGGCGGACAGATTCAAATAAATCCTTTGTCAGCTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9950.18 Da
• Isoelectric Point: 5.8375

>AT201549 WP_059201942.1 NZ_CP074137:554204-554473 [Serratia sp. JSRIV006]
MTQTTLNLRIDTELKTDFLEAAKAMDRNGSQLIRDFMRETVQRQHDIWFRDQVQAGIAQANRGEVLSGESVEASAVAWRE
AAAKKLAGS

Nucleotide

• Length: 270 bp

>AT201549 NZ_CP098511:1366294-1366596 [Aquimarina sp. ERC-38]
ATGTTTTTTATTGAGAAAACAAAAGAGTTTAATAAATGGTTTAGAAAATTAAAAGACTCAAAAGCTAAAACAAAAATTCT
TTATAGAATTCAAAGATTAGAAAATGACGAACATTTTGGAGATTGCAAACCTGTAGGTGATGGAATTAAAGAAATTAGAA
TAAATTTTGCTAAAGAATATCGTATTTATTTCAAGGAGAAAAATGGGAGAATAATTATTTTACTAATAGGTGGAGATAAA
TCAACTCAACAAAAAGATATTAAGAAAGCAAAAGAAATTTGGAATAAATTAAATAATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y8XL57