Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 6273311..6273950 Replicon chromosome
Accession NZ_CP074132
Organism Nocardiopsis akebiae strain HDS12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KGD83_RS26875 Protein ID WP_212641707.1
Coordinates 6273531..6273950 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KGD83_RS26870 Protein ID WP_212641706.1
Coordinates 6273311..6273526 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGD83_RS26850 (KGD83_26850) 6268699..6269331 - 633 WP_212641703.1 amino-acid N-acetyltransferase -
KGD83_RS26855 (KGD83_26855) 6269523..6269846 - 324 WP_212641704.1 LuxR C-terminal-related transcriptional regulator -
KGD83_RS26860 (KGD83_26860) 6270550..6272154 - 1605 WP_212644624.1 bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX -
KGD83_RS26865 (KGD83_26865) 6272251..6273207 + 957 WP_212641705.1 cation diffusion facilitator family transporter -
KGD83_RS26870 (KGD83_26870) 6273311..6273526 + 216 WP_212641706.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KGD83_RS26875 (KGD83_26875) 6273531..6273950 + 420 WP_212641707.1 PIN domain nuclease Toxin
KGD83_RS26880 (KGD83_26880) 6274001..6274783 - 783 WP_013155972.1 type III pantothenate kinase -
KGD83_RS26885 (KGD83_26885) 6274848..6277466 - 2619 WP_212641708.1 L-aspartate oxidase -
KGD83_RS26890 (KGD83_26890) 6277553..6278422 - 870 WP_212641709.1 pantoate--beta-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-35)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15863.06 Da        Isoelectric Point: 6.4792

>T201544 WP_212641707.1 NZ_CP074132:6273531-6273950 [Nocardiopsis akebiae]
VTKTYLLDTSAWLEYLGGTGSETHLFVRQLRDDRENVATTDPVICELLSGAKTEKAFFQLDAMLQAQTRLTVEPTFDFRE
SAMLYRGARSKGKTIRKHMDCLIAAVALRTDAVLVHCDRDFDDLAEVFPRLRVQRHDQN

Download         Length: 420 bp

>T201544 NZ_CP098505:724024-724443 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8232.12 Da        Isoelectric Point: 4.1653

>AT201544 WP_212641706.1 NZ_CP074132:6273311-6273526 [Nocardiopsis akebiae]
MSRTNIDIDDELVTTVMEKYGLRTKREAVDFGLRHVAGSGDRYEMMLELEGSDVWEGDLDEMRRSGFEDEK

Download         Length: 216 bp

>AT201544 NZ_CP098505:723788-724024 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References