Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2446397..2446992 Replicon chromosome
Accession NZ_CP074120
Organism Escherichia coli strain EC16

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KGQ53_RS11745 Protein ID WP_000239579.1
Coordinates 2446397..2446747 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KGQ53_RS11750 Protein ID WP_001223208.1
Coordinates 2446741..2446992 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGQ53_RS11725 (2441843) 2441843..2442865 - 1023 WP_001295197.1 ABC transporter permease -
KGQ53_RS11730 (2442879) 2442879..2444381 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
KGQ53_RS11735 (2444521) 2444521..2445477 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KGQ53_RS11740 (2445787) 2445787..2446317 + 531 WP_000055072.1 inorganic diphosphatase -
KGQ53_RS11745 (2446397) 2446397..2446747 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KGQ53_RS11750 (2446741) 2446741..2446992 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KGQ53_RS11755 (2447204) 2447204..2447545 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KGQ53_RS11760 (2447548) 2447548..2451327 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T201517 WP_000239579.1 NZ_CP074120:c2446747-2446397 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T201517 NZ_CP098475:c1986-1708 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT201517 WP_001223208.1 NZ_CP074120:c2446992-2446741 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT201517 NZ_CP098475:c2171-1986 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References