Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5129188..5130869 Replicon chromosome
Accession NZ_CP074116
Organism Klebsiella pneumoniae subsp. pneumoniae strain kpn-hnqyy

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag KGB32_RS25330 Protein ID WP_002885155.1
Coordinates 5129188..5130105 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag KGB32_RS25335 Protein ID WP_004151732.1
Coordinates 5130111..5130869 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGB32_RS25310 (KGB32_25310) 5124494..5126014 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
KGB32_RS25315 (KGB32_25315) 5126011..5127009 + 999 WP_002885172.1 ribose ABC transporter permease -
KGB32_RS25320 (KGB32_25320) 5127040..5127981 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
KGB32_RS25325 (KGB32_25325) 5128056..5129063 + 1008 WP_004151731.1 carbohydrate kinase family protein -
KGB32_RS25330 (KGB32_25330) 5129188..5130105 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KGB32_RS25335 (KGB32_25335) 5130111..5130869 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
KGB32_RS25340 (KGB32_25340) 5130955..5131683 - 729 WP_002885152.1 response regulator transcription factor -
KGB32_RS25345 (KGB32_25345) 5131956..5134103 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
KGB32_RS25350 (KGB32_25350) 5134333..5135019 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5037346..5134229 96883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T201491 WP_002885155.1 NZ_CP074116:c5130105-5129188 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T201491 NZ_CP098455:3287106-3287759 [Spongiibacter taiwanensis]
ATGGCCTACGACTACAGCGCGACCCTTAACCCACAAAAGGCCCTGATCTGGCGAATTGTCCACCGGGACAATATCCCCTG
GATTCTGGATAACGGGTTGCATAGCGGCAACAGCACCGTGCAATCCCCGGGTTGGGTCCCGATTGGTAACCCGGAGTTGA
CCGATAAACGTGCTACCCATGCAGTACCTGCAGGCCCGGGCGGTTATCTGAATGACTATGTGCCGTTTTACTTCACCCCC
TTTTCGCCAATGATGAAGAATATCCACAGCGGTCGTGCAGGCGTCCACCGGCGACGCAATGACGAAATTGTCATTTTGGT
ATCGAGTCTGTACAAGGTGCAGAACCTGGGCCTGCCCTTTGTATTCAGCGACGGCCATGCCTATTACGCCTGGTCGAACT
TTTATACCGATCTGGCGGATCTGGACAAAATCGACTGGCCCATTATCCAGGCCCGGGACTTCAAGCGAGACCCGGATGAC
CCGGCCAAGTTTGAGCGCTATCAGGCCGAGGCCCTGATTCACCAGCACTGCCCGGTCGCTGCTCTGGAAGGGATGATTTG
TTACACTGCCAAGACTCAGGCTCAACTGGATAACTGGCTGCAAGCCCGCCAGATACGCATGCCGGTTTACGCACGCTCAG
GGTGGTACTTCTGA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT201491 WP_004151732.1 NZ_CP074116:c5130869-5130111 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT201491 NZ_CP098455:3287759-3288826 [Spongiibacter taiwanensis]
ATGATCACATACCTACAAGGCAATTTGCTGGATGCCGAGGTGGAAGCCTTGGTGAATACCGTCAATACCGTCGGGGTGAT
GGGCAAGGGTATTGCACTGATGTTTAAAGAGCGCTTTCCTCAGAATATGCAGGAATATGCCCAGGCCTGTAAGGCGGGAG
AGGTGCAAACCGGGCGTATGTTTGTCACCAAAACCGGTGAGCTGATGGGTCCCAAGTGGGTGGTGAATTTCCCCACCAAG
CAGCACTGGAAGGCCAAGTCCAAAATGGAATGGATTGAAAGTGGCCTGGAGGACTTGCGCCGCTTTATTGAGGAAAACCG
CCTGCAGTCCATTGCCATTCCGCCCTTGGGCGCGGGTAACGGCGGCCTGAATTGGCAGGAGGTCAAGCCTCTGGTTGAGC
GAGCTTTGGGCGATCTGGAGGGCGTGAATATCTTGGTGTTTGAGCCTACCGCCAAATATCAGAATGTCAGCAAAAAATCC
GGTGTAAACACCTTAACTCCTGCTCGGGCTCTGGTGGCCGAGCTGGTGCGCCGCTATTGGATATTGGGCATGGAGTGCAG
CCTGCTTGAGATTCAAAAACTCGCCTGGTTCCTGCAGCGGGTGATTGATGCCAAAGGGCTGGATAATCAGCTGAAGCTGG
ATTTTGAAGCCAATTATTACGGGCCCTATGCCAATAATCTTACCCATTTGCTGAATGCCCTGGATGGCAGCTACCTGAAG
GCCGACAAACGGATACCCGACAGTCAGCCGCTGGATGTGATCGCCTTTAACGATAATAAGAAAGACTTTGTGGAAGCCTA
TTTGGCGACTGAGGCCAAGGCTTACCTGCCCACGCTTGAACAAACCAGTCAGCTTATCGATGGATTTGAATCGCCCTTCG
GGATGGAATTACTGTCCACGGTGGATTGGTTAGTGGTGAAGGACAATTGTGAGTTGGCGCTGGGGTCGATCAAAGAAGGC
ATGGCCCGCTGGCCAGCGGGCAAACAGTGGGCGGAGCGTAAGCTGAATCTGTTTGATGACAAGAGCCTGCAGATTGCGAT
TGATCGTTTGAAGGCTGTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References