Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 5054440..5054966 | Replicon | chromosome |
| Accession | NZ_CP074116 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain kpn-hnqyy | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KGB32_RS24955 | Protein ID | WP_000323025.1 |
| Coordinates | 5054679..5054966 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KGB32_RS24950 | Protein ID | WP_000534858.1 |
| Coordinates | 5054440..5054679 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KGB32_RS24925 (KGB32_24925) | 5049502..5050206 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| KGB32_RS24930 (KGB32_24930) | 5050438..5051778 | + | 1341 | WP_000589001.1 | ISNCY family transposase | - |
| KGB32_RS24935 (KGB32_24935) | 5052199..5052510 | + | 312 | Protein_4904 | transposase | - |
| KGB32_RS24945 (KGB32_24945) | 5053854..5054177 | + | 324 | WP_224948387.1 | cation transporter dimerization domain-containing protein | - |
| KGB32_RS28800 | 5054311..5054415 | - | 105 | Protein_4907 | hypothetical protein | - |
| KGB32_RS24950 (KGB32_24950) | 5054440..5054679 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KGB32_RS24955 (KGB32_24955) | 5054679..5054966 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KGB32_RS24960 (KGB32_24960) | 5055038..5055196 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| KGB32_RS24965 (KGB32_24965) | 5055799..5056773 | + | 975 | WP_004181899.1 | hypothetical protein | - |
| KGB32_RS24970 (KGB32_24970) | 5056971..5057348 | - | 378 | WP_004181901.1 | hypothetical protein | - |
| KGB32_RS24975 (KGB32_24975) | 5058038..5059105 | + | 1068 | WP_004181903.1 | hypothetical protein | - |
| KGB32_RS24980 (KGB32_24980) | 5059261..5059608 | + | 348 | WP_004181904.1 | hypothetical protein | - |
| KGB32_RS24985 (KGB32_24985) | 5059687..5059920 | + | 234 | WP_004181905.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 5037346..5134229 | 96883 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T201490 WP_000323025.1 NZ_CP074116:5054679-5054966 [Klebsiella pneumoniae subsp. pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T201490 NZ_CP098455:705718-706011 [Spongiibacter taiwanensis]
ATGCCCCCATTCCTGCTCACCTCCGCTGCCCGAAAAGACATTATTGATATTGGACGATTTACCTCTGAGAAGTGGGGAAA
GCGTCAACGCGATAAATACCTCAAGCAACTTGACGATGCCTTCAGGTTGCTTGCTCGGCAGCCTGAAATTGGCCACGCTG
CGGAAGACATAAAGCCAGGCTATAAGAAGTTTAGCCAAGGCAGCCATATCATATTTTATCGATCTGGCACGGAGTCCAAG
ATTGTTGTGGTCCGCATTCTCCACAATAGTATGGATGTGGACCAGCACCTCTAG
ATGCCCCCATTCCTGCTCACCTCCGCTGCCCGAAAAGACATTATTGATATTGGACGATTTACCTCTGAGAAGTGGGGAAA
GCGTCAACGCGATAAATACCTCAAGCAACTTGACGATGCCTTCAGGTTGCTTGCTCGGCAGCCTGAAATTGGCCACGCTG
CGGAAGACATAAAGCCAGGCTATAAGAAGTTTAGCCAAGGCAGCCATATCATATTTTATCGATCTGGCACGGAGTCCAAG
ATTGTTGTGGTCCGCATTCTCCACAATAGTATGGATGTGGACCAGCACCTCTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT201490 WP_000534858.1 NZ_CP074116:5054440-5054679 [Klebsiella pneumoniae subsp. pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT201490 NZ_CP098455:705479-705718 [Spongiibacter taiwanensis]
ATGGCTAGAAATACCAGCATTACCCTCGGCCCCCATTTTGATGAATTCATTGCTGCGCAACTTGAAAATGGCCGCTATGG
CTCCGCGAGCGAAGTAGTGAGAGCAGGGCTGCGCTTGCTTGAAGAGACTGAGAGCAAACTTGAAAGGTTGCGGCGCCTCC
TTGATGAAGGCGAGCAAAGCGGGATAGCCGAGTACTCACTTGACAGTGTTATCGCAGAATTGGATAACGAAGCTCACTAA
ATGGCTAGAAATACCAGCATTACCCTCGGCCCCCATTTTGATGAATTCATTGCTGCGCAACTTGAAAATGGCCGCTATGG
CTCCGCGAGCGAAGTAGTGAGAGCAGGGCTGCGCTTGCTTGAAGAGACTGAGAGCAAACTTGAAAGGTTGCGGCGCCTCC
TTGATGAAGGCGAGCAAAGCGGGATAGCCGAGTACTCACTTGACAGTGTTATCGCAGAATTGGATAACGAAGCTCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|