201489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4918543..4919059 Replicon chromosome
Accession NZ_CP074116
Organism Klebsiella pneumoniae subsp. pneumoniae strain kpn-hnqyy

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KGB32_RS24250 Protein ID WP_002886902.1
Coordinates 4918543..4918827 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KGB32_RS24255 Protein ID WP_002886901.1
Coordinates 4918817..4919059 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGB32_RS24225 (KGB32_24225) 4914027..4914290 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KGB32_RS24230 (KGB32_24230) 4914420..4914593 + 174 WP_002886906.1 hypothetical protein -
KGB32_RS24235 (KGB32_24235) 4914596..4915339 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KGB32_RS24240 (KGB32_24240) 4915696..4917834 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KGB32_RS24245 (KGB32_24245) 4918075..4918539 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KGB32_RS24250 (KGB32_24250) 4918543..4918827 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGB32_RS24255 (KGB32_24255) 4918817..4919059 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KGB32_RS24260 (KGB32_24260) 4919137..4921047 - 1911 WP_004152270.1 PRD domain-containing protein -
KGB32_RS24265 (KGB32_24265) 4921070..4922224 - 1155 WP_002886900.1 lactonase family protein -
KGB32_RS24270 (KGB32_24270) 4922290..4923030 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T201489 WP_002886902.1 NZ_CP074116:c4918827-4918543 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T201489 NZ_CP098451:29077-29364 [Proteus mirabilis]
ATGATGTATTCGGTTAAATTTAGAAAAGATGCAGAAAAGGAATGGAAAAAATTAGATAAAACCATTCAATCTCAATTTGC
CAAACAATTAATAAAACGATGTGAAAATCCACATGTAGCATCTGCAAAACTGAGAAATATGCCGAATTGCTATAAAATTA
AACTTCGTGCATCAGGTTTTAGATTGGTCTATCAAGTTATTGACGATATGTTAATTATTGCAGTTGTTGCCGTTGGCAAG
CGGGAAAAAAGTCAGGTTTATAATCTTGCCAGTGAACGCTTAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT201489 WP_002886901.1 NZ_CP074116:c4919059-4918817 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT201489 NZ_CP098451:28829-29080 [Proteus mirabilis]
ATGCCAAATACGATTTTAAGTGATACAACAGCCAGCGTCAGTGAACTCAAAAAAAACCCAATGGCGACAGTTAACGCAGG
TTTAGGCTATCCCGTAGCCATTTTAAACCGTAATCAACCTGCTTTTTACTGTGTTCCTGCTGAGTTATATGAGCAAATAC
TTGATGCGCTAGACGATAACGAACTTGCAAAGCTGGTCAAAGAACGAGAATCACAACCTCTTGTCGATATTAATTTAGCC
GAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References