Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2694337..2695361 Replicon chromosome
Accession NZ_CP074112
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag KGF88_RS12920 Protein ID WP_153827349.1
Coordinates 2694789..2695361 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag KGF88_RS12915 Protein ID WP_153827348.1
Coordinates 2694337..2694789 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGF88_RS12890 (KGF88_12935) 2689494..2689967 - 474 WP_153827292.1 HNH endonuclease domain-containing protein -
KGF88_RS12895 (KGF88_12940) 2690012..2690755 - 744 WP_110077105.1 IS21-like element helper ATPase IstB -
KGF88_RS12900 (KGF88_12945) 2690752..2692251 - 1500 WP_257119941.1 IS21 family transposase -
KGF88_RS12905 (KGF88_12950) 2692379..2693602 - 1224 WP_153827346.1 class I SAM-dependent methyltransferase -
KGF88_RS12910 (KGF88_12955) 2693657..2694076 - 420 WP_153827347.1 secondary thiamine-phosphate synthase enzyme YjbQ -
KGF88_RS12915 (KGF88_12960) 2694337..2694789 + 453 WP_153827348.1 helix-turn-helix domain-containing protein Antitoxin
KGF88_RS12920 (KGF88_12965) 2694789..2695361 + 573 WP_153827349.1 PIN domain-containing protein Toxin
KGF88_RS12925 (KGF88_12970) 2695552..2697405 + 1854 WP_153827350.1 DUF885 domain-containing protein -
KGF88_RS12930 (KGF88_12975) 2697415..2698749 - 1335 WP_153827351.1 HipA domain-containing protein -
KGF88_RS12935 (KGF88_12980) 2698736..2698963 - 228 WP_162014647.1 helix-turn-helix domain-containing protein -
KGF88_RS12940 (KGF88_12985) 2699256..2699546 + 291 WP_153827353.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2690012..2690755 743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

Helix-turn-helix domain, group 17

(80-127)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21740.93 Da        Isoelectric Point: 6.3773

>T201473 WP_153827349.1 NZ_CP074112:2694789-2695361 [Idiomarina loihiensis]
MSSSYTVIFDACVLYPAPLRSLLMYLALSGEFRARWTNDIHDEWIRNVLANRPDLTREQLENVRNLMDKHVPGAIVQNYH
PLISSISLPDEDDRHVVAAAIQTRAEAIVTFNLKDFPDNQLSQYNLKAIHPDDFITDLMELNIVAVIQAVRHHRASLKNP
PFTATQYLDCLLKQKLPEAVSRLSEFKALF

Download         Length: 573 bp

>T201473 NZ_CP098446:c4021970-4020657 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGGATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTCGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACAGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCCATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTCGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTTCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16752.24 Da        Isoelectric Point: 5.7816

>AT201473 WP_153827348.1 NZ_CP074112:2694337-2694789 [Idiomarina loihiensis]
MNTYEQLPTAQESALAKLCSQELAAVIETKLDVQSLSLSSPDGQLKQVEIPVSALRLMVNLLTELGEGNTVKLVPIHAEL
TTQEAADLLNVSRPTVIKLLDDGTVPFHRVGNRRKVRFNDIRQYQNQLEQKRLKALNELSKMDQELGLGY

Download         Length: 453 bp

>AT201473 NZ_CP098446:c4022228-4021971 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References