Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1743354..1743943 Replicon chromosome
Accession NZ_CP074112
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KGF88_RS08385 Protein ID WP_153827410.1
Coordinates 1743689..1743943 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KGF88_RS08380 Protein ID WP_110076035.1
Coordinates 1743354..1743692 (-) Length 113 a.a.

Genomic Context

KGF88_RS08360KGF88_RS08365KGF88_RS08370KGF88_RS08375KGF88_RS08380KGF88_RS08385KGF88_RS08390KGF88_RS08395KGF88_RS08400KGF88_RS08405
Location: 1738966..1740465 (1500 bp)
Type: Others
Protein ID: WP_257119919.1
Location: 1740462..1741205 (744 bp)
Type: Others
Protein ID: WP_110077105.1
Location: 1741519..1742178 (660 bp)
Type: Others
Protein ID: WP_110076038.1
Location: 1742321..1742623 (303 bp)
Type: Others
Protein ID: WP_110076037.1
Location: 1743354..1743692 (339 bp)
Type: Antitoxin
Protein ID: WP_110076035.1
Location: 1743689..1743943 (255 bp)
Type: Toxin
Protein ID: WP_153827410.1
Location: 1744102..1744680 (579 bp)
Type: Others
Protein ID: WP_034733594.1
Location: 1744759..1747377 (2619 bp)
Type: Others
Protein ID: WP_153827357.1
Location: 1747486..1747833 (348 bp)
Type: Others
Protein ID: WP_153827358.1
Location: 1747922..1748749 (828 bp)
Type: Others
Protein ID: WP_153827359.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KGF88_RS08360 (KGF88_08385)1738966..1740465+1500WP_257119919.1IS21 family transposase-
KGF88_RS08365 (KGF88_08390)1740462..1741205+744WP_110077105.1IS21-like element helper ATPase IstB-
KGF88_RS08370 (KGF88_08395)1741519..1742178-660WP_110076038.1outer membrane beta-barrel protein-
KGF88_RS08375 (KGF88_08400)1742321..1742623-303WP_110076037.1HigA family addiction module antitoxin-
KGF88_RS08380 (KGF88_08410)1743354..1743692-339WP_110076035.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
KGF88_RS08385 (KGF88_08415)1743689..1743943-255WP_153827410.1type II toxin-antitoxin system HicA family toxinToxin
KGF88_RS08390 (KGF88_08420)1744102..1744680-579WP_034733594.1hypothetical protein-
KGF88_RS08395 (KGF88_08425)1744759..1747377-2619WP_153827357.1AAA family ATPase-
KGF88_RS08400 (KGF88_08430)1747486..1747833-348WP_153827358.1hypothetical protein-
KGF88_RS08405 (KGF88_08435)1747922..1748749-828WP_153827359.1DUF6430 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1738109..175344815339
-flankIS/Tn--1740462..1741205743
-insideIntegron--1742835..17473774542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-79)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9570.06 Da        Isoelectric Point: 11.2749

>T201471 WP_153827410.1 NZ_CP074112:c1743943-1743689 [Idiomarina loihiensis]
MKRKHQKTLEAIFARPVSGNVQWRDIEALFVEIGAEVSEREGSRVAVVLFGEVRVFHRPHPSPSTDKGAVASIRKWLKQH
RITP

Download         Length: 255 bp

>T201471 NZ_CP098446:c3360430-3359492 [Proteus mirabilis]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCTTTGCTCATAAGAATGCTGCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAATTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGGCAGTTCAAGAGTCTGTTGAATACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCGCTGAATGAGAAATTTCAGGCAGAAT
TTGATGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCTTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATTATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATAAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12754.46 Da        Isoelectric Point: 8.0070

>AT201471 WP_110076035.1 NZ_CP074112:c1743692-1743354 [Idiomarina loihiensis]
MNTMTYDGYHAKIEYDSELDAFRGEILGLNGGADFYGRNPKELRAEFKKSLRVFLEVCEEKSIEPRRRYSGKFNLRISPE
LHEQLAITAQVKGKSVNKLAQEALQKELSNAG

Download         Length: 339 bp

>AT201471 NZ_CP098446:c3361214-3360423 [Proteus mirabilis]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References