Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1743354..1743943 Replicon chromosome
Accession NZ_CP074112
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KGF88_RS08385 Protein ID WP_153827410.1
Coordinates 1743689..1743943 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KGF88_RS08380 Protein ID WP_110076035.1
Coordinates 1743354..1743692 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGF88_RS08360 (KGF88_08385) 1738966..1740465 + 1500 WP_257119919.1 IS21 family transposase -
KGF88_RS08365 (KGF88_08390) 1740462..1741205 + 744 WP_110077105.1 IS21-like element helper ATPase IstB -
KGF88_RS08370 (KGF88_08395) 1741519..1742178 - 660 WP_110076038.1 outer membrane beta-barrel protein -
KGF88_RS08375 (KGF88_08400) 1742321..1742623 - 303 WP_110076037.1 HigA family addiction module antitoxin -
KGF88_RS08380 (KGF88_08410) 1743354..1743692 - 339 WP_110076035.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KGF88_RS08385 (KGF88_08415) 1743689..1743943 - 255 WP_153827410.1 type II toxin-antitoxin system HicA family toxin Toxin
KGF88_RS08390 (KGF88_08420) 1744102..1744680 - 579 WP_034733594.1 hypothetical protein -
KGF88_RS08395 (KGF88_08425) 1744759..1747377 - 2619 WP_153827357.1 AAA family ATPase -
KGF88_RS08400 (KGF88_08430) 1747486..1747833 - 348 WP_153827358.1 hypothetical protein -
KGF88_RS08405 (KGF88_08435) 1747922..1748749 - 828 WP_153827359.1 DUF6430 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1738109..1753448 15339
- flank IS/Tn - - 1740462..1741205 743
- inside Integron - - 1742835..1747377 4542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-79)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9570.06 Da        Isoelectric Point: 11.2749

>T201471 WP_153827410.1 NZ_CP074112:c1743943-1743689 [Idiomarina loihiensis]
MKRKHQKTLEAIFARPVSGNVQWRDIEALFVEIGAEVSEREGSRVAVVLFGEVRVFHRPHPSPSTDKGAVASIRKWLKQH
RITP

Download         Length: 255 bp

>T201471 NZ_CP098446:c3360430-3359492 [Proteus mirabilis]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCTTTGCTCATAAGAATGCTGCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAATTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGGCAGTTCAAGAGTCTGTTGAATACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCGCTGAATGAGAAATTTCAGGCAGAAT
TTGATGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCTTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATTATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATAAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12754.46 Da        Isoelectric Point: 8.0070

>AT201471 WP_110076035.1 NZ_CP074112:c1743692-1743354 [Idiomarina loihiensis]
MNTMTYDGYHAKIEYDSELDAFRGEILGLNGGADFYGRNPKELRAEFKKSLRVFLEVCEEKSIEPRRRYSGKFNLRISPE
LHEQLAITAQVKGKSVNKLAQEALQKELSNAG

Download         Length: 339 bp

>AT201471 NZ_CP098446:c3361214-3360423 [Proteus mirabilis]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References