Detailed information of TA system TA201469

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1736833..1737380
• Replicon: chromosome
• Accession: NZ_CP074112
• Organism: Idiomarina loihiensis strain SN11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGF88_RS08335
• Protein ID: WP_110076041.1
• Coordinates: 1736833..1737135 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7FV42
• Locus tag: KGF88_RS08340
• Protein ID: WP_022990189.1
• Coordinates: 1737123..1737380 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGF88_RS08305 (KGF88_08330)	1732946..1733443	-	498	WP_153825985.1	hypothetical protein	-
KGF88_RS08310 (KGF88_08335)	1733448..1734674	-	1227	WP_153825986.1	ATP-binding protein	-
KGF88_RS08315 (KGF88_08340)	1734955..1735272	+	318	WP_153825987.1	quaternary ammonium compound efflux SMR transporter SugE	-
KGF88_RS08320 (KGF88_08345)	1735482..1735637	+	156	WP_153825988.1	hypothetical protein	-
KGF88_RS08325 (KGF88_08350)	1736145..1736444	-	300	WP_110076043.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KGF88_RS08330 (KGF88_08355)	1736441..1736680	-	240	WP_110076042.1	addiction module protein	-
KGF88_RS08335 (KGF88_08360)	1736833..1737135	-	303	WP_110076041.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGF88_RS08340 (KGF88_08365)	1737123..1737380	-	258	WP_022990189.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KGF88_RS08345 (KGF88_08370)	1737457..1737726	-	270	WP_110076040.1	CopG family transcriptional regulator	-
KGF88_RS08350 (KGF88_08375)	1737716..1737979	-	264	WP_110076039.1	BrnT family toxin	-
KGF88_RS08355 (KGF88_08380)	1738109..1738504	-	396	WP_202912491.1	hypothetical protein	-
KGF88_RS08360 (KGF88_08385)	1738966..1740465	+	1500	WP_257119919.1	IS21 family transposase	-
KGF88_RS08365 (KGF88_08390)	1740462..1741205	+	744	WP_110077105.1	IS21-like element helper ATPase IstB	-
KGF88_RS08370 (KGF88_08395)	1741519..1742178	-	660	WP_110076038.1	outer membrane beta-barrel protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1740462..1741205	743

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11540.25 Da
• Isoelectric Point: 4.3648

>T201469 WP_110076041.1 NZ_CP074112:c1737135-1736833 [Idiomarina loihiensis]
MAEVIWTEPALQELDAIAEYIALDNPAAASDLVKEVFGKTERLENFPKSGRIPPELPDSVYREVVVPPCRIFYREDEQRV
LVLYVMREERQLRAFMLGNS

Nucleotide

• Length: 303 bp

>T201469 NZ_CP098446:c1523768-1523583 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9887.41 Da
• Isoelectric Point: 8.5042

>AT201469 WP_022990189.1 NZ_CP074112:c1737380-1737123 [Idiomarina loihiensis]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT201469 NZ_CP098446:c1523536-1523123 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAAATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1I1I6C4