Detailed information of TA system TA201467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-RHH
• Location: 1179553..1180109
• Replicon: chromosome
• Accession: NZ_CP074112
• Organism: Idiomarina loihiensis strain SN11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KGF88_RS05620
• Protein ID: WP_257119983.1
• Coordinates: 1179553..1179798 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KGF88_RS05625
• Protein ID: WP_110076941.1
• Coordinates: 1179822..1180109 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KGF88_RS05595 (KGF88_05625)	1175506..1175937	-	432	WP_228759564.1	potassium channel family protein	-
KGF88_RS05600 (KGF88_05630)	1176429..1176896	-	468	WP_153827110.1	GIY-YIG nuclease family protein	-
KGF88_RS05605 (KGF88_05635)	1177217..1177600	-	384	WP_126801850.1	hypothetical protein	-
KGF88_RS05610 (KGF88_05640)	1177721..1178152	+	432	WP_092841881.1	hypothetical protein	-
KGF88_RS05615 (KGF88_05645)	1178261..1178971	+	711	WP_153827109.1	hypothetical protein	-
KGF88_RS05620 (KGF88_05650)	1179553..1179798	-	246	WP_257119983.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KGF88_RS05625 (KGF88_05655)	1179822..1180109	-	288	WP_110076941.1	ribbon-helix-helix protein, CopG family	Antitoxin
KGF88_RS05630 (KGF88_05660)	1180214..1180783	-	570	WP_153827108.1	tellurite resistance methyltransferase TehB	-
KGF88_RS05635 (KGF88_05665)	1180898..1181245	+	348	WP_228759563.1	hexameric tyrosine-coordinated heme protein	-
KGF88_RS05640 (KGF88_05670)	1181213..1182166	-	954	WP_153827107.1	helix-turn-helix domain-containing protein	-
KGF88_RS05645 (KGF88_05675)	1182264..1183160	+	897	WP_228759562.1	MBL fold metallo-hydrolase	-
KGF88_RS05650 (KGF88_05680)	1183213..1183725	-	513	WP_194928203.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9313.56 Da
• Isoelectric Point: 5.0348

>T201467 WP_257119983.1 NZ_CP074112:c1179798-1179553 [Idiomarina loihiensis]
IRDREQIYDFIENDNPVAALQLDNQVSSSVANLSEYPEIGREGRVLGTRELVVHANYIVVYDFSKDALRILRILHAAMKW
P

Nucleotide

• Length: 246 bp

>T201467 NZ_CP098439:c93817-93401 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10993.19 Da
• Isoelectric Point: 9.9158

>AT201467 WP_110076941.1 NZ_CP074112:c1180109-1179822 [Idiomarina loihiensis]
MSDATFTFRVNDELKSEFSKAARSRDRSSAQLLRDFMREYVQQQERLAEHDSWFREQVKQGLDSANAGNLVPAGDVEAKF
AARRALTQRNIDKQR

Nucleotide

• Length: 288 bp

>AT201467 NZ_CP098439:c94044-93814 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA