Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4692021..4692537 Replicon chromosome
Accession NZ_CP074098
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain C_cip

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag KFV01_RS22700 Protein ID WP_000220578.1
Coordinates 4692253..4692537 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KFV01_RS22695 Protein ID WP_000212724.1
Coordinates 4692021..4692263 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV01_RS22675 (4687037) 4687037..4688170 + 1134 WP_212634552.1 amidohydrolase/deacetylase family metallohydrolase -
KFV01_RS22680 (4688154) 4688154..4689272 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KFV01_RS22685 (4689269) 4689269..4690009 + 741 WP_000779255.1 KDGP aldolase family protein -
KFV01_RS22690 (4690026) 4690026..4691939 + 1914 WP_001212148.1 BglG family transcription antiterminator -
KFV01_RS22695 (4692021) 4692021..4692263 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFV01_RS22700 (4692253) 4692253..4692537 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFV01_RS22705 (4692541) 4692541..4693005 - 465 WP_212634372.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFV01_RS22710 (4693139) 4693139..4695277 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
KFV01_RS22715 (4695686) 4695686..4697338 - 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T201457 WP_000220578.1 NZ_CP074098:4692253-4692537 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T201457 NZ_CP098438:2085553-2085656 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT201457 WP_000212724.1 NZ_CP074098:4692021-4692263 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT201457 NZ_CP098438:c2085658-2085513 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References