Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3206376..3207036 Replicon chromosome
Accession NZ_CP074098
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain C_cip

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KFV01_RS15605 Protein ID WP_000244756.1
Coordinates 3206376..3206789 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KFV01_RS15610 Protein ID WP_000351186.1
Coordinates 3206770..3207036 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV01_RS15585 (3202317) 3202317..3204050 - 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -
KFV01_RS15590 (3204056) 3204056..3204769 - 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFV01_RS15595 (3204793) 3204793..3205689 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KFV01_RS15600 (3205802) 3205802..3206323 + 522 WP_001055885.1 flavodoxin FldB -
KFV01_RS15605 (3206376) 3206376..3206789 - 414 WP_000244756.1 protein YgfX Toxin
KFV01_RS15610 (3206770) 3206770..3207036 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KFV01_RS15615 (3207286) 3207286..3208266 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
KFV01_RS15620 (3208382) 3208382..3209041 - 660 WP_000250289.1 hemolysin III family protein -
KFV01_RS15625 (3209205) 3209205..3209516 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KFV01_RS15630 (3209675) 3209675..3211108 + 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T201450 WP_000244756.1 NZ_CP074098:c3206789-3206376 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T201450 NZ_CP098437:c3050139-3049885 [Streptomyces lydicamycinicus]
GTGAGGCTCGTCTTCGAAGATCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCTCACTCGGAT
TAACAAGCTCATCGAGGACGTCAAGCGTGACCCCTTCGAGGGAATCGGTAAGCCCGAGCCCCTCAAGTACCACTTGCCCG
GAGCGTGGTCGAGGCGAATCGACGATGAGCACCGCCTCGTCTACCTGGTCACGGGCAAGGAGATCGTGATCCTCGCAGCT
CGCTATCACTACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT201450 WP_000351186.1 NZ_CP074098:c3207036-3206770 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201450 NZ_CP098437:c3050417-3050136 [Streptomyces lydicamycinicus]
ATGTCCATAACCGCGAGCGAAGCCCGCAAGGCTCTCTTCCCGCTGATCAAGAAGGTCAACGACGATCACGAGGCCATCGA
GATCGTCTCCAAGCACGGCAACGCCGTGCTCGTCTCGGCCGAGGACTACGCCGCACTGCGCGAAGGCTCGTACCTGCTGC
GCTCGCCTGCGAACGCACGGCGGTTGCTCAAGGCGTACGAGAACGCCTTGGGCAACATCAACGTGTCGGAGCGCGAGCTG
ATCGATCCGGACGCAGTGGACCCTGCTGCGGGTGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References