201449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3047674..3048488 Replicon chromosome
Accession NZ_CP074098
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain C_cip

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag KFV01_RS14890 Protein ID WP_000971653.1
Coordinates 3047961..3048488 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KFV01_RS14885 Protein ID WP_000855694.1
Coordinates 3047674..3047964 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV01_RS14855 (3043624) 3043624..3044274 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
KFV01_RS14860 (3044731) 3044731..3045174 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KFV01_RS14865 (3045605) 3045605..3046054 + 450 WP_023225038.1 hypothetical protein -
KFV01_RS14870 (3046039) 3046039..3046386 + 348 WP_001555786.1 DUF1493 family protein -
KFV01_RS14875 (3046659) 3046659..3046985 - 327 WP_000393295.1 hypothetical protein -
KFV01_RS14880 (3047226) 3047226..3047404 + 179 Protein_2924 IS3 family transposase -
KFV01_RS14885 (3047674) 3047674..3047964 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KFV01_RS14890 (3047961) 3047961..3048488 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
KFV01_RS14895 (3048561) 3048561..3048763 - 203 Protein_2927 IS5/IS1182 family transposase -
KFV01_RS14900 (3049113) 3049113..3049769 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
KFV01_RS14905 (3049941) 3049941..3050462 - 522 WP_212634516.1 cytoplasmic protein -
KFV01_RS14910 (3050621) 3050621..3053188 + 2568 WP_023181887.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3048561..3048737 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T201449 WP_000971653.1 NZ_CP074098:3047961-3048488 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T201449 NZ_CP098421:c39634-38771 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAGTTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGAAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTGTTGTCATTGATAATGATACCTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACACCTTATTCTAATCGTATGACAGAAGCACTTATTAGCCGTTTAAG
CGATCAAGGCTATAATTTAGTGATTGAAGGCACAGGACGAACAACAGACGTTCCTATTCAAACAGCCACAATGCTACAAG
CCAAAGGTTATGAAACAAAAACGTACGCCATGGCAGTACCCAAAATTGAATCATACTTAGGAACGATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCTAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT201449 WP_000855694.1 NZ_CP074098:3047674-3047964 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT201449 NZ_CP098421:c39908-39636 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACTTTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTAAAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References