201440

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1626788..1627310 Replicon chromosome
Accession NZ_CP074098
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain C_cip

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag KFV01_RS07940 Protein ID WP_000221345.1
Coordinates 1626788..1627072 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag KFV01_RS07945 Protein ID WP_000885424.1
Coordinates 1627062..1627310 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV01_RS07920 (1622863) 1622863..1624371 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
KFV01_RS07925 (1624416) 1624416..1624904 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
KFV01_RS07930 (1625097) 1625097..1626176 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
KFV01_RS07935 (1626228) 1626228..1626617 - 390 WP_000194089.1 RidA family protein -
KFV01_RS07940 (1626788) 1626788..1627072 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFV01_RS07945 (1627062) 1627062..1627310 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFV01_RS07950 (1627462) 1627462..1627581 + 120 Protein_1560 type II and III secretion system -
KFV01_RS07955 (1627667) 1627667..1627999 + 333 WP_212634604.1 DUF1493 family protein -
KFV01_RS07960 (1628142) 1628142..1629050 + 909 WP_212634474.1 hypothetical protein -
KFV01_RS07965 (1629106) 1629106..1629820 - 715 Protein_1563 helix-turn-helix domain-containing protein -
KFV01_RS07970 (1630628) 1630628..1632094 - 1467 WP_024147874.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T201440 WP_000221345.1 NZ_CP074098:c1627072-1626788 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T201440 NZ_CP098418:501723-501839 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT201440 WP_000885424.1 NZ_CP074098:c1627310-1627062 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT201440 NZ_CP098418:c501955-501750 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References