Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 528229..528849 Replicon chromosome
Accession NZ_CP074098
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain C_cip

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KFV01_RS02390 Protein ID WP_001280991.1
Coordinates 528229..528447 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KFV01_RS02395 Protein ID WP_000344807.1
Coordinates 528475..528849 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV01_RS02350 (523453) 523453..524022 + 570 WP_000779802.1 YbaY family lipoprotein -
KFV01_RS02355 (524055) 524055..524444 - 390 WP_023224410.1 MGMT family protein -
KFV01_RS02365 (524675) 524675..526225 - 1551 WP_000213145.1 EAL domain-containing protein -
KFV01_RS02370 (526450) 526450..526710 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KFV01_RS02375 (526716) 526716..526856 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KFV01_RS02380 (526912) 526912..527382 - 471 WP_000136183.1 YlaC family protein -
KFV01_RS02385 (527499) 527499..528050 - 552 WP_001278793.1 maltose O-acetyltransferase -
KFV01_RS02390 (528229) 528229..528447 - 219 WP_001280991.1 HHA domain-containing protein Toxin
KFV01_RS02395 (528475) 528475..528849 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KFV01_RS02400 (529345) 529345..532494 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KFV01_RS02405 (532517) 532517..533710 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - acrB / acrA / allS / allA / allR / allB / allC / allD / fimI / fimC / fimD / fimH / fimF 368943..611768 242825


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T201439 WP_001280991.1 NZ_CP074098:c528447-528229 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T201439 NZ_CP098418:c313323-313228 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT201439 WP_000344807.1 NZ_CP074098:c528849-528475 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT201439 NZ_CP098418:313129-313193 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References