Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4692080..4692596 Replicon chromosome
Accession NZ_CP074096
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag KFV00_RS22700 Protein ID WP_000220578.1
Coordinates 4692312..4692596 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KFV00_RS22695 Protein ID WP_000212724.1
Coordinates 4692080..4692322 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV00_RS22675 (4687091) 4687091..4688224 + 1134 WP_212634371.1 amidohydrolase/deacetylase family metallohydrolase -
KFV00_RS22680 (4688208) 4688208..4689326 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KFV00_RS22685 (4689323) 4689323..4690063 + 741 WP_000779255.1 KDGP aldolase family protein -
KFV00_RS22690 (4690080) 4690080..4691993 + 1914 WP_001212148.1 BglG family transcription antiterminator -
KFV00_RS22695 (4692080) 4692080..4692322 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFV00_RS22700 (4692312) 4692312..4692596 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFV00_RS22705 (4692601) 4692601..4693065 - 465 WP_212634372.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KFV00_RS22710 (4693197) 4693197..4695335 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
KFV00_RS22715 (4695744) 4695744..4697396 - 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T201433 WP_000220578.1 NZ_CP074096:4692312-4692596 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T201433 NZ_CP098408:c1646888-1646634 [Alcaligenes sp. DN25]
ATGAAAATCATCTCGTTTTCAGAAGCGCGCAACAGCTTGAAAGCTGTACTGGATAGCGTAGTCGATGACGCCAGCACCAC
CATCATCACGCGTCGTGATGCGGAAGACGCTGTAGTCATGTCACTCGATTACTACAACAGCTTGATGGAAACCGTCCATC
TGCTGCGCTCCCCCGCTAATGCGGAACACCTGAGCCGCTCTATCGAACAATATCGTGCTGGCAAAGCCATGCCACGCGAG
CTGAGCGATGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT201433 WP_000212724.1 NZ_CP074096:4692080-4692322 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT201433 NZ_CP098408:c1646641-1646378 [Alcaligenes sp. DN25]
ATGACTGACCGTTTGTTATGCTGGACTGACGCTGCCTGGATTGACTATGTGTATTGGCAAGGCCAGGACCGCAAGACATT
GAAGCGTATCAACAGACTGATAGAGGAAGTACGACGTGCGCCATTCGATGGCATAGGCAAACCTGAAGCGCTTAAAGAAA
ATCTGTCCGGCTTTTGGTCAAGACGCATTGATGACACGAATCGCCTGGTCTATGCCGTAGACAAGGCAAGCATCACCATC
ATTTCTTGTCGTTATCATTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References