Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3838199..3838959 Replicon chromosome
Accession NZ_CP074096
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag KFV00_RS18675 Protein ID WP_023225088.1
Coordinates 3838199..3838684 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag KFV00_RS18680 Protein ID WP_072106018.1
Coordinates 3838672..3838959 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV00_RS18645 (3833269) 3833269..3833931 + 663 WP_000747548.1 OmpA family lipoprotein -
KFV00_RS18650 (3834150) 3834150..3835124 + 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
KFV00_RS18655 (3835174) 3835174..3835884 - 711 WP_000190524.1 DUF3053 domain-containing protein -
KFV00_RS18660 (3836323) 3836323..3836613 + 291 WP_000455790.1 HTH-type transcriptional regulator -
KFV00_RS18665 (3836902) 3836902..3837114 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
KFV00_RS18670 (3837288) 3837288..3837827 + 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
KFV00_RS18675 (3838199) 3838199..3838684 - 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
KFV00_RS18680 (3838672) 3838672..3838959 - 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
KFV00_RS18685 (3839148) 3839148..3839615 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
KFV00_RS18690 (3839760) 3839760..3840107 - 348 Protein_3671 IS3 family transposase -
KFV00_RS18695 (3840260) 3840260..3842329 - 2070 WP_023225090.1 glycine--tRNA ligase subunit beta -
KFV00_RS18700 (3842339) 3842339..3843250 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
KFV00_RS18705 (3843389) 3843389..3843691 - 303 WP_023206518.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T201429 WP_023225088.1 NZ_CP074096:c3838684-3838199 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T201429 NZ_CP098403:c737850-737581 [Lactobacillus kefiranofaciens subsp. kefirgranum]
ATGATTTTAAAATATCATGGCAGGATTAAAAACTCAGCTAAGCCTGATTTAAAGAAGATTAAGCGAAGTAATCTGAAAGA
TAATTTTCAAGATATTATAGATCAACTCAAAAAAGATCCTTATAAAAAGAATCAAGGATTTGAAAAATTAGAACCACCAA
TTTTAGGAAAATATTCTCGAAGAATCAATATAAAACATCGAGTTGTTTATACTGTTGATGATGTTAATAAGATAGTAAGT
ATTTACTCGGCCTGGTCACATTATGAATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT201429 WP_072106018.1 NZ_CP074096:c3838959-3838672 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp

>AT201429 NZ_CP098403:c738113-737847 [Lactobacillus kefiranofaciens subsp. kefirgranum]
ATGGATGCAACAATTTATACTCCCACAGGAGCAAGACGTAATTTATTCAATCTTATCAAGCAAGTTAATAAAAACCATAC
TCCAGTTAATATTGAATCTACAAAAGATAAAGCAGAAAGTGCTGTGTTAATAAGTAAATCCGACTGGGACGCTATTCAGG
AGACTCTTTATCTTGAGTCCAATGGTGTAGGAGAAGTTGTGAGAAAACGTGAAAAGGACAATTCAGGTTTTACTGATATT
GATGATATTAACTGGGATGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References