Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 3728363..3728949 | Replicon | chromosome |
| Accession | NZ_CP074096 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | E8XF70 |
| Locus tag | KFV00_RS18200 | Protein ID | WP_001521773.1 |
| Coordinates | 3728363..3728731 (-) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | M7SDJ3 |
| Locus tag | KFV00_RS18205 | Protein ID | WP_001520924.1 |
| Coordinates | 3728728..3728949 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV00_RS18180 (3723904) | 3723904..3724974 | - | 1071 | WP_001646570.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
| KFV00_RS18185 (3724976) | 3724976..3725821 | - | 846 | WP_000572196.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| KFV00_RS18190 (3725818) | 3725818..3726705 | - | 888 | WP_000099303.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| KFV00_RS18195 (3726785) | 3726785..3728101 | - | 1317 | WP_023224166.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| KFV00_RS18200 (3728363) | 3728363..3728731 | - | 369 | WP_001521773.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| KFV00_RS18205 (3728728) | 3728728..3728949 | - | 222 | WP_001520924.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KFV00_RS18210 (3729082) | 3729082..3729795 | - | 714 | WP_000416114.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| KFV00_RS18215 (3729797) | 3729797..3730564 | - | 768 | WP_000082083.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| KFV00_RS18220 (3730561) | 3730561..3731838 | - | 1278 | WP_000803766.1 | branched chain amino acid ABC transporter permease LivM | - |
| KFV00_RS18225 (3731835) | 3731835..3732761 | - | 927 | WP_000003005.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| KFV00_RS18230 (3732821) | 3732821..3733930 | - | 1110 | WP_023224165.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3723167..3739183 | 16016 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13587.92 Da Isoelectric Point: 7.3190
>T201428 WP_001521773.1 NZ_CP074096:c3728731-3728363 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLKQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA
Download Length: 369 bp
>T201428 NZ_CP098400:1430618-1430902 [Alkaliflexus sp. Ai-910]
ATGGGAACATCAAAATTTGATATAGCTGACTATTTAGATAGTAACGAGATGATTGCTGAATATCTTAATACTGTTTTAGC
AGAGGGAAACGAAGCCGATGTAATTGTAGCTATTGGACATATAGCAAAATCAATCGGCATGACCAAAATTGCTCAAGAAA
CTGGATTAAGTAGGACAAGTTTATACAAAGCTTTATCGGAAGGTGCAAAACCTCAGTTTGAGACGATTATGAAAGTATTA
AAAGCAATAGGCGGACAGATACAAATAAATCCCATGAATGCATAA
ATGGGAACATCAAAATTTGATATAGCTGACTATTTAGATAGTAACGAGATGATTGCTGAATATCTTAATACTGTTTTAGC
AGAGGGAAACGAAGCCGATGTAATTGTAGCTATTGGACATATAGCAAAATCAATCGGCATGACCAAAATTGCTCAAGAAA
CTGGATTAAGTAGGACAAGTTTATACAAAGCTTTATCGGAAGGTGCAAAACCTCAGTTTGAGACGATTATGAAAGTATTA
AAAGCAATAGGCGGACAGATACAAATAAATCCCATGAATGCATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8152.14 Da Isoelectric Point: 5.0775
>AT201428 WP_001520924.1 NZ_CP074096:c3728949-3728728 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK
Download Length: 222 bp
>AT201428 NZ_CP098400:1430314-1430613 [Alkaliflexus sp. Ai-910]
ATGTATATAATTGAGAAGACAGAAGAATTTGACAAATGGCTGAGAAAACTTAAAGATTTAAGAGCCAAAGCCAAAATATT
GTTTCGTATTCAAAAGATTGAGAATGATGAACACTTTGGCGACTGCAAACTTGTTGGGAATGGTATTCGGGAGTTGAAAA
TTGACTTTGCTAAAGGATACAGGGTATACTTTAAAGAATCTGACGGAAAAATCATTATCCTGCTTATTGGTGGAGATAAA
TCAACTCAGCAGAGAGACATTGAAAAGGCAAAAGAGATTTTAAAACGAATTAAAAAGTAA
ATGTATATAATTGAGAAGACAGAAGAATTTGACAAATGGCTGAGAAAACTTAAAGATTTAAGAGCCAAAGCCAAAATATT
GTTTCGTATTCAAAAGATTGAGAATGATGAACACTTTGGCGACTGCAAACTTGTTGGGAATGGTATTCGGGAGTTGAAAA
TTGACTTTGCTAAAGGATACAGGGTATACTTTAAAGAATCTGACGGAAAAATCATTATCCTGCTTATTGGTGGAGATAAA
TCAACTCAGCAGAGAGACATTGAAAAGGCAAAAGAGATTTTAAAACGAATTAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A607IPC3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6C6Z871 |