Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3047667..3048481 Replicon chromosome
Accession NZ_CP074096
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag KFV00_RS14890 Protein ID WP_000971653.1
Coordinates 3047954..3048481 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KFV00_RS14885 Protein ID WP_000855694.1
Coordinates 3047667..3047957 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV00_RS14855 (3043617) 3043617..3044267 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
KFV00_RS14860 (3044724) 3044724..3045167 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KFV00_RS14865 (3045598) 3045598..3046047 + 450 WP_023225038.1 hypothetical protein -
KFV00_RS14870 (3046032) 3046032..3046379 + 348 WP_001555786.1 DUF1493 family protein -
KFV00_RS14875 (3046652) 3046652..3046978 - 327 WP_000393295.1 hypothetical protein -
KFV00_RS14880 (3047219) 3047219..3047397 + 179 Protein_2924 IS3 family transposase -
KFV00_RS14885 (3047667) 3047667..3047957 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KFV00_RS14890 (3047954) 3047954..3048481 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
KFV00_RS14895 (3048554) 3048554..3048756 - 203 Protein_2927 IS5/IS1182 family transposase -
KFV00_RS14900 (3049106) 3049106..3049762 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
KFV00_RS14905 (3049934) 3049934..3050458 - 525 WP_212634310.1 cytoplasmic protein -
KFV00_RS14910 (3050617) 3050617..3053184 + 2568 WP_023181887.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3048554..3048730 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T201425 WP_000971653.1 NZ_CP074096:3047954-3048481 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T201425 NZ_CP098357:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT201425 WP_000855694.1 NZ_CP074096:3047667-3047957 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT201425 NZ_CP098357:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References