Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4786094..4786670 Replicon chromosome
Accession NZ_CP074094
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag KFU99_RS23095 Protein ID WP_001131963.1
Coordinates 4786094..4786381 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag KFU99_RS23100 Protein ID WP_000063142.1
Coordinates 4786368..4786670 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU99_RS23085 (4781204) 4781204..4784713 - 3510 WP_001043485.1 type I restriction-modification system endonuclease -
KFU99_RS23090 (4784911) 4784911..4785825 + 915 WP_000290512.1 restriction endonuclease -
KFU99_RS23095 (4786094) 4786094..4786381 + 288 WP_001131963.1 BrnT family toxin Toxin
KFU99_RS23100 (4786368) 4786368..4786670 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
KFU99_RS23105 (4786748) 4786748..4787704 - 957 WP_000187838.1 GTPase -
KFU99_RS23110 (4787715) 4787715..4787918 - 204 WP_000460616.1 YbdD/YjiX family protein -
KFU99_RS23115 (4788013) 4788013..4790163 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T201410 WP_001131963.1 NZ_CP074094:4786094-4786381 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T201410 NZ_CP098354:c47544-47266 [Klebsiella pneumoniae]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATAGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAACCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGAGGATTGCATACTGTACAGAAGTGGCCATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT201410 WP_000063142.1 NZ_CP074094:4786368-4786670 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT201410 NZ_CP098354:c47813-47544 [Klebsiella pneumoniae]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTACTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References