Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3838081..3838841 Replicon chromosome
Accession NZ_CP074094
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag KFU99_RS18680 Protein ID WP_023225088.1
Coordinates 3838081..3838566 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag KFU99_RS18685 Protein ID WP_072106018.1
Coordinates 3838554..3838841 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU99_RS18650 (3833151) 3833151..3833813 + 663 WP_000747548.1 OmpA family lipoprotein -
KFU99_RS18655 (3834032) 3834032..3835006 + 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
KFU99_RS18660 (3835056) 3835056..3835766 - 711 WP_000190524.1 DUF3053 domain-containing protein -
KFU99_RS18665 (3836205) 3836205..3836495 + 291 WP_000455790.1 HTH-type transcriptional regulator -
KFU99_RS18670 (3836784) 3836784..3836996 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
KFU99_RS18675 (3837170) 3837170..3837709 + 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
KFU99_RS18680 (3838081) 3838081..3838566 - 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
KFU99_RS18685 (3838554) 3838554..3838841 - 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
KFU99_RS18690 (3839022) 3839022..3839489 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
KFU99_RS18695 (3839631) 3839631..3839936 - 306 Protein_3669 IS3 family transposase -
KFU99_RS18700 (3840119) 3840119..3842188 - 2070 WP_023220761.1 glycine--tRNA ligase subunit beta -
KFU99_RS18705 (3842198) 3842198..3843109 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
KFU99_RS18710 (3843248) 3843248..3843550 - 303 WP_023206518.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T201405 WP_023225088.1 NZ_CP074094:c3838566-3838081 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T201405 NZ_CP098352:c4882170-4881886 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT201405 WP_072106018.1 NZ_CP074094:c3838841-3838554 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp

>AT201405 NZ_CP098352:c4882402-4882160 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References