Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3047573..3048387 Replicon chromosome
Accession NZ_CP074094
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag KFU99_RS14890 Protein ID WP_000971653.1
Coordinates 3047860..3048387 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag KFU99_RS14885 Protein ID WP_000855694.1
Coordinates 3047573..3047863 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU99_RS14855 (3043523) 3043523..3044173 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
KFU99_RS14860 (3044630) 3044630..3045073 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
KFU99_RS14865 (3045504) 3045504..3045953 + 450 WP_023225038.1 hypothetical protein -
KFU99_RS14870 (3045938) 3045938..3046285 + 348 WP_001555786.1 DUF1493 family protein -
KFU99_RS14875 (3046558) 3046558..3046884 - 327 WP_000393295.1 hypothetical protein -
KFU99_RS14880 (3047125) 3047125..3047303 + 179 Protein_2923 IS3 family transposase -
KFU99_RS14885 (3047573) 3047573..3047863 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
KFU99_RS14890 (3047860) 3047860..3048387 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
KFU99_RS14895 (3048460) 3048460..3048662 - 203 Protein_2926 IS5/IS1182 family transposase -
KFU99_RS14900 (3049012) 3049012..3049668 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
KFU99_RS14905 (3049840) 3049840..3050361 - 522 WP_212634516.1 cytoplasmic protein -
KFU99_RS14910 (3050520) 3050520..3053087 + 2568 WP_023181887.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3048460..3048636 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T201401 WP_000971653.1 NZ_CP074094:3047860-3048387 [Salmonella enterica subsp. enterica serovar Typhimurium]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T201401 NZ_CP098352:2075677-2075779 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT201401 WP_000855694.1 NZ_CP074094:3047573-3047863 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT201401 NZ_CP098352:c2075786-2075641 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References