201392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1626717..1627239 Replicon chromosome
Accession NZ_CP074094
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag KFU99_RS07940 Protein ID WP_000221345.1
Coordinates 1626717..1627001 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag KFU99_RS07945 Protein ID WP_000885424.1
Coordinates 1626991..1627239 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU99_RS07920 (1622792) 1622792..1624300 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
KFU99_RS07925 (1624345) 1624345..1624833 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
KFU99_RS07930 (1625026) 1625026..1626105 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
KFU99_RS07935 (1626157) 1626157..1626546 - 390 WP_000194089.1 RidA family protein -
KFU99_RS07940 (1626717) 1626717..1627001 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFU99_RS07945 (1626991) 1626991..1627239 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFU99_RS07950 (1627391) 1627391..1627510 + 120 Protein_1560 type II and III secretion system -
KFU99_RS07955 (1627596) 1627596..1627928 + 333 WP_212634686.1 DUF1493 family protein -
KFU99_RS07960 (1628071) 1628071..1628979 + 909 WP_212634696.1 hypothetical protein -
KFU99_RS07965 (1629035) 1629035..1629749 - 715 Protein_1563 helix-turn-helix domain-containing protein -
KFU99_RS07970 (1630557) 1630557..1632023 - 1467 WP_024147874.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T201392 WP_000221345.1 NZ_CP074094:c1627001-1626717 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T201392 NZ_CP098350:c4880697-4880413 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT201392 WP_000885424.1 NZ_CP074094:c1627239-1626991 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT201392 NZ_CP098350:c4880929-4880687 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References