Detailed information of TA system TA201391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 528222..528842
• Replicon: chromosome
• Accession: NZ_CP074094
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: KFU99_RS02390
• Protein ID: WP_001280991.1
• Coordinates: 528222..528440 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: KFU99_RS02395
• Protein ID: WP_000344807.1
• Coordinates: 528468..528842 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU99_RS02350 (523446)	523446..524015	+	570	WP_000779802.1	YbaY family lipoprotein	-
KFU99_RS02355 (524048)	524048..524437	-	390	WP_023224410.1	MGMT family protein	-
KFU99_RS02365 (524668)	524668..526218	-	1551	WP_000213145.1	EAL domain-containing protein	-
KFU99_RS02370 (526443)	526443..526703	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
KFU99_RS02375 (526709)	526709..526849	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
KFU99_RS02380 (526905)	526905..527375	-	471	WP_000136183.1	YlaC family protein	-
KFU99_RS02385 (527492)	527492..528043	-	552	WP_001278793.1	maltose O-acetyltransferase	-
KFU99_RS02390 (528222)	528222..528440	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
KFU99_RS02395 (528468)	528468..528842	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
KFU99_RS02400 (529338)	529338..532487	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
KFU99_RS02405 (532510)	532510..533703	-	1194	WP_001039199.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T201391 WP_001280991.1 NZ_CP074094:c528440-528222 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T201391 NZ_CP098350:c4777656-4777123 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT201391 WP_000344807.1 NZ_CP074094:c528842-528468 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT201391 NZ_CP098350:c4777933-4777667 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0