Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 20096..20621 | Replicon | plasmid pSLT |
| Accession | NZ_CP074093 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | KFK83_RS23590 | Protein ID | WP_001159863.1 |
| Coordinates | 20316..20621 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | KFK83_RS23585 | Protein ID | WP_000813641.1 |
| Coordinates | 20096..20314 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFK83_RS23560 (KFK83_23560) | 15383..15764 | + | 382 | Protein_20 | YgiW/YdeI family stress tolerance OB fold protein | - |
| KFK83_RS23565 (KFK83_23565) | 15933..16377 | + | 445 | Protein_21 | tyrosine-type recombinase/integrase | - |
| KFK83_RS23570 (KFK83_23570) | 16636..17625 | - | 990 | WP_001527061.1 | RepB family plasmid replication initiator protein | - |
| KFK83_RS23575 (KFK83_23575) | 18119..18415 | - | 297 | WP_001687482.1 | hypothetical protein | - |
| KFK83_RS24205 | 18427..18855 | + | 429 | Protein_24 | hypothetical protein | - |
| KFK83_RS23580 (KFK83_23580) | 18899..19420 | - | 522 | WP_010999942.1 | hypothetical protein | - |
| KFK83_RS23585 (KFK83_23585) | 20096..20314 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| KFK83_RS23590 (KFK83_23590) | 20316..20621 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| KFK83_RS23595 (KFK83_23595) | 20623..20913 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| KFK83_RS23600 (KFK83_23600) | 20910..21431 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| KFK83_RS23605 (KFK83_23605) | 21466..22248 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| KFK83_RS23610 (KFK83_23610) | 22257..22808 | + | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| KFK83_RS23615 (KFK83_23615) | 22995..23483 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| KFK83_RS23620 (KFK83_23620) | 23477..23962 | + | 486 | WP_000905606.1 | membrane protein | - |
| KFK83_RS23625 (KFK83_23625) | 24239..24526 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| KFK83_RS23630 (KFK83_23630) | 24682..25242 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..93933 | 93933 | |
| - | flank | IS/Tn | - | - | 25309..25659 | 350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T201387 WP_001159863.1 NZ_CP074093:20316-20621 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T201387 NZ_CP098350:814939-815349 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT201387 WP_000813641.1 NZ_CP074093:20096-20314 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT201387 NZ_CP098350:814692-814958 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |