Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 3837748..3838508 | Replicon | chromosome |
Accession | NZ_CP074092 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm |
Toxin (Protein)
Gene name | tacT | Uniprot ID | Q57IH1 |
Locus tag | KFK83_RS18680 | Protein ID | WP_000533909.1 |
Coordinates | 3837748..3838233 (-) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | M7RHS4 |
Locus tag | KFK83_RS18685 | Protein ID | WP_000965886.1 |
Coordinates | 3838221..3838508 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFK83_RS18650 (3832818) | 3832818..3833480 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
KFK83_RS18655 (3833699) | 3833699..3834673 | + | 975 | WP_000804674.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
KFK83_RS18660 (3834723) | 3834723..3835433 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
KFK83_RS18665 (3835872) | 3835872..3836162 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
KFK83_RS18670 (3836451) | 3836451..3836663 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
KFK83_RS18675 (3836837) | 3836837..3837376 | + | 540 | WP_000047149.1 | copper-binding periplasmic metallochaperone CueP | - |
KFK83_RS18680 (3837748) | 3837748..3838233 | - | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
KFK83_RS18685 (3838221) | 3838221..3838508 | - | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
KFK83_RS18690 (3838686) | 3838686..3839153 | - | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
KFK83_RS18695 (3839325) | 3839325..3839600 | - | 276 | Protein_3671 | IS3 family transposase | - |
KFK83_RS18700 (3839782) | 3839782..3841851 | - | 2070 | WP_001291736.1 | glycine--tRNA ligase subunit beta | - |
KFK83_RS18705 (3841861) | 3841861..3842772 | - | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
KFK83_RS18710 (3842911) | 3842911..3843213 | - | 303 | WP_000605590.1 | YsaB family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T201381 WP_000533909.1 NZ_CP074092:c3838233-3837748 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T201381 NZ_CP098349:c72359-72210 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT201381 WP_000965886.1 NZ_CP074092:c3838508-3838221 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT201381 NZ_CP098349:72403-72464 [Klebsiella pneumoniae]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 7F36 | |
PDB | 7AK8 | |
PDB | 5FVJ |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 7AK8 | |
AlphaFold DB | A0A3V2JDX2 |