Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3206014..3206674 Replicon chromosome
Accession NZ_CP074092
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KFK83_RS15610 Protein ID WP_000244756.1
Coordinates 3206014..3206427 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KFK83_RS15615 Protein ID WP_000351186.1
Coordinates 3206408..3206674 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFK83_RS15590 (3201955) 3201955..3203688 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
KFK83_RS15595 (3203694) 3203694..3204407 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFK83_RS15600 (3204431) 3204431..3205327 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KFK83_RS15605 (3205440) 3205440..3205961 + 522 WP_001055885.1 flavodoxin FldB -
KFK83_RS15610 (3206014) 3206014..3206427 - 414 WP_000244756.1 protein YgfX Toxin
KFK83_RS15615 (3206408) 3206408..3206674 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KFK83_RS15620 (3206924) 3206924..3207904 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
KFK83_RS15625 (3208020) 3208020..3208679 - 660 WP_000250289.1 hemolysin III family protein -
KFK83_RS15630 (3208843) 3208843..3209154 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KFK83_RS15635 (3209313) 3209313..3210746 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T201378 WP_000244756.1 NZ_CP074092:c3206427-3206014 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T201378 NZ_CP098348:c6108-5803 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT201378 WP_000351186.1 NZ_CP074092:c3206674-3206408 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201378 NZ_CP098348:c6328-6110 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References