Detailed information of TA system TA201356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4798578..4799094
• Replicon: chromosome
• Accession: NZ_CP074087
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain MRSN752165

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2A2BGN7
• Locus tag: KF579_RS23335
• Protein ID: WP_009486548.1
• Coordinates: 4798578..4798862 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: KF579_RS23340
• Protein ID: WP_002886901.1
• Coordinates: 4798852..4799094 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KF579_RS23310 (4793995)	4793995..4794258	-	264	WP_014908078.1	PTS sugar transporter subunit IIB	-
KF579_RS23315 (4794388)	4794388..4794561	+	174	WP_032433782.1	hypothetical protein	-
KF579_RS23320 (4794564)	4794564..4795307	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
KF579_RS23325 (4795664)	4795664..4797802	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
KF579_RS23330 (4798110)	4798110..4798574	+	465	WP_002886903.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KF579_RS23335 (4798578)	4798578..4798862	-	285	WP_009486548.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KF579_RS23340 (4798852)	4798852..4799094	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KF579_RS23345 (4799172)	4799172..4801082	-	1911	WP_009486549.1	PRD domain-containing protein	-
KF579_RS23350 (4801105)	4801105..4802259	-	1155	WP_002886900.1	lactonase family protein	-
KF579_RS23355 (4802326)	4802326..4803066	-	741	WP_009486551.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.95 Da
• Isoelectric Point: 10.4951

>T201356 WP_009486548.1 NZ_CP074087:c4798862-4798578 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T201356 NZ_CP098343:740529-741014 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT201356 WP_002886901.1 NZ_CP074087:c4799094-4798852 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT201356 NZ_CP098343:740239-740532 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A2A2BGN7

Antitoxin

• AlphaFold DB: A0A0H3GLP0