201354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4060835..4061454 Replicon chromosome
Accession NZ_CP074087
Organism Klebsiella pneumoniae subsp. pneumoniae strain MRSN752165

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KF579_RS19895 Protein ID WP_002892050.1
Coordinates 4061236..4061454 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KF579_RS19890 Protein ID WP_002892066.1
Coordinates 4060835..4061209 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF579_RS19880 (4055987) 4055987..4057180 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KF579_RS19885 (4057203) 4057203..4060349 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KF579_RS19890 (4060835) 4060835..4061209 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KF579_RS19895 (4061236) 4061236..4061454 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KF579_RS19900 (4061617) 4061617..4062183 + 567 WP_002892030.1 maltose O-acetyltransferase -
KF579_RS19905 (4062155) 4062155..4062295 - 141 WP_004147370.1 hypothetical protein -
KF579_RS19910 (4062316) 4062316..4062786 + 471 WP_020802585.1 YlaC family protein -
KF579_RS19915 (4062761) 4062761..4064212 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
KF579_RS19920 (4064313) 4064313..4065011 + 699 WP_023287311.1 GNAT family protein -
KF579_RS19925 (4065008) 4065008..4065148 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KF579_RS19930 (4065148) 4065148..4065411 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T201354 WP_002892050.1 NZ_CP074087:4061236-4061454 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T201354 NZ_CP098343:327067-327435 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT201354 WP_002892066.1 NZ_CP074087:4060835-4061209 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT201354 NZ_CP098343:326849-327070 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References